Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Dec;54(12):884-7.
doi: 10.4111/kju.2013.54.12.884. Epub 2013 Dec 10.

Spermatocytic seminoma with sarcoma: an indication for adjuvant chemotherapy in localized disease

David Wetherell  1 , Nathan Lawrentschuk  1 , Dennis Gyomber  1
Affiliations

Spermatocytic seminoma with sarcoma: an indication for adjuvant chemotherapy in localized disease

David Wetherell et al. Korean J Urol. 2013 Dec.

Abstract

Spermatocytic seminoma (SCS) with sarcoma is an extremely rare testicular tumor with only 11 cases previously described in the literature. We present the 12th case of SCS with sarcoma in a 29-year-old male. SCS itself is an uncommon germ cell tumor with a relatively indolent clinical course that mostly affects males around the fifth decade of life. Sarcomatous differentiation of SCS occurs in 5% to 6% of cases and correlates with a higher possibility of metastatic disease and a poor prognosis. Clinically, this tumor manifests as a slow-growing testicular mass often with an accelerated period of secondary growth. After a concise review of the literature, we conclude that SCS with sarcoma should be treated by radical inguinal orchidectomy with strong consideration given to adjuvant chemotherapy.

Keywords: Orchiectomy; Sarcoma; Seminoma; Testicular neoplasms; Testis.

PubMed Disclaimer

Conflict of interest statement

The authors have nothing to disclose.

Figures

FIG. 1
FIG. 1
Gray-scale ultrasound scan demonstrating a large cystic mass in the right testis.
FIG. 2
FIG. 2
Microscopic chondroid-type change demonstrating sarcoma differentiation (×200).
FIG. 3
FIG. 3
Microscopic demonstration of the interface between the sarcoma (top right) and seminoma (bottom left) elements (×40).
See this image and copyright information in PMC

References

    1. True LD, Otis CN, Delprado W, Scully RE, Rosai J. Spermatocytic seminoma of testis with sarcomatous transformation: a report of five cases. Am J Surg Pathol. 1988;12:75–82. - PubMed
    1. Menon S, Karpate A, Desai S. Spermatocytic seminoma with rhabdomyosarcomatous differentiation: a case report with a review of the literature. J Cancer Res Ther. 2009;5:213–215. - PubMed
    1. Floyd C, Ayala AG, Logothetis CJ, Silva EG. Spermatocytic seminoma with associated sarcoma of the testis. Cancer. 1988;61:409–414. - PubMed
    1. Malagon HD, Valdez AM, Moran CA, Suster S. Germ cell tumors with sarcomatous components: a clinicopathologic and immunohistochemical study of 46 cases. Am J Surg Pathol. 2007;31:1356–1362. - PubMed
    1. Henley JD, Ulbright TM. Seminoma: a review with emphasis on morphologic patterns and differential diagnosis. Pathol Case Rev. 2005;10:167–175.

LinkOut - more resources