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Comment
. 2014 Feb;15(2):170-1.
doi: 10.4161/cbt.27629. Epub 2014 Jan 14.

Bidirectional conversion of intestinal epithelial cells: NFκB is key

Amelie Boquoi  1
Affiliations
Comment

Bidirectional conversion of intestinal epithelial cells: NFκB is key

Amelie Boquoi. Cancer Biol Ther. 2014 Feb.

Abstract

NFκB represents a key transcription factor within the inflammatory tumor microenvironment; however, NFκB's function in tumor-initiating cells has not been examined yet. A recent Cell paper by Schwitalla et al. reports that NFκB modulates Wnt signaling and shows that enhanced Wnt activation induces dedifferentiation of nonstem cells that acquire tumor-initiating capacity.

Keywords: EMT; Lgr5; NFκB; Wnt signaling; chronic inflammation; dedifferentiation; microenvironment.

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