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Comment
. 2014 Jan;16(1):23-5.
doi: 10.1038/ncb2899.

Autophagy chews Fap to promote apoptosis

Sanket Joshi  1 , Kevin M Ryan  1
Affiliations
Comment

Autophagy chews Fap to promote apoptosis

Sanket Joshi et al. Nat Cell Biol. 2014 Jan.

Abstract

Macroautophagy is a key regulator of cellular integrity and viability, but how the process facilitates apoptosis has remained poorly defined. It has now become clear that autophagy degrades the Fap-1 protein phosphatase, a critical negative regulator of apoptotic cell death signalled by the TNF receptor family member, Fas.

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References

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