Statin use is not associated with reduced risk of skin cancer: a meta-analysis

doi:10.1038/bjc.2013.762

Meta-Analysis

. 2014 Feb 4;110(3):802-7.

doi: 10.1038/bjc.2013.762. Epub 2013 Dec 24.

Statin use is not associated with reduced risk of skin cancer: a meta-analysis

X Li¹, X B Wu¹, Q Chen¹

Affiliations

PMID: 24366301
PMCID: PMC3915126
DOI: 10.1038/bjc.2013.762

Meta-Analysis

Statin use is not associated with reduced risk of skin cancer: a meta-analysis

X Li et al. Br J Cancer. 2014.

. 2014 Feb 4;110(3):802-7.

doi: 10.1038/bjc.2013.762. Epub 2013 Dec 24.

Authors

X Li¹, X B Wu¹, Q Chen¹

Affiliation

¹ Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China.

PMID: 24366301
PMCID: PMC3915126
DOI: 10.1038/bjc.2013.762

Abstract

Background: There is contradictory evidence about the association between statin and skin cancer.

Methods: Literature search in PubMed and Web of Science was undertaken up to June 2013. Pooled relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated.

Result: A total of 21 articles with 29 studies were identified. No association was found between statin and skin cancer among neither melanoma (RR, 0.94; 95% CI, 0.85-1.04) nor non-melanoma skin cancer (RR, 1.03; 95% CI, 0.90-1.19).

Conclusion: Our meta-analysis does not support a potential role of statin use in the prevention of skin cancer.

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References

1. Bonovas S, Nikolopoulos G, Filioussi K, Peponi E, Bagos P, Sitaras NM. Can statin therapy reduce the risk of melanoma? A meta-analysis of randomized controlled trials. Eur J Epidemiol. 2010;25 (1:29–35. - PubMed
1. Carroll RP, Segundo DS, Hollowood K, Marafioti T, Clark TG, Harden PN, Wood KJ. Immune phenotype predicts risk for posttransplantation squamous cell carcinoma. J Am Soc Nephrol. 2010;21 (4:713–722. - PMC - PubMed
1. Clendening JW, Pandyra A, Boutros PC, El Ghamrasni S, Khosravi F, Trentin GA, Martirosyan A, Hakem A, Hakem R, Jurisica I, Penn LZ. Dysregulation of the mevalonate pathway promotes transformation. Proc Natl Acad Sci USA. 2010;107 (34:15051–15056. - PMC - PubMed
1. Clendening JW, Penn LZ. Targeting tumor cell metabolism with statins. Oncogene. 2012;31 (48:4967–4978. - PubMed
1. Coimbra M, Banciu M, Fens MH, de Smet L, Cabaj M, Metselaar JM, Storm G, Schiffelers RM. Liposomal pravastatin inhibits tumor growth by targeting cancer-related inflammation. J Control Release. 2010;148 (3:303–310. - PubMed

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[1] Bonovas S, Nikolopoulos G, Filioussi K, Peponi E, Bagos P, Sitaras NM. Can statin therapy reduce the risk of melanoma? A meta-analysis of randomized controlled trials. Eur J Epidemiol. 2010;25 (1:29–35. - PubMed

[2] Bonovas S, Nikolopoulos G, Filioussi K, Peponi E, Bagos P, Sitaras NM. Can statin therapy reduce the risk of melanoma? A meta-analysis of randomized controlled trials. Eur J Epidemiol. 2010;25 (1:29–35. - PubMed

[3] Carroll RP, Segundo DS, Hollowood K, Marafioti T, Clark TG, Harden PN, Wood KJ. Immune phenotype predicts risk for posttransplantation squamous cell carcinoma. J Am Soc Nephrol. 2010;21 (4:713–722. - PMC - PubMed

[4] Carroll RP, Segundo DS, Hollowood K, Marafioti T, Clark TG, Harden PN, Wood KJ. Immune phenotype predicts risk for posttransplantation squamous cell carcinoma. J Am Soc Nephrol. 2010;21 (4:713–722. - PMC - PubMed

[5] Clendening JW, Pandyra A, Boutros PC, El Ghamrasni S, Khosravi F, Trentin GA, Martirosyan A, Hakem A, Hakem R, Jurisica I, Penn LZ. Dysregulation of the mevalonate pathway promotes transformation. Proc Natl Acad Sci USA. 2010;107 (34:15051–15056. - PMC - PubMed

[6] Clendening JW, Pandyra A, Boutros PC, El Ghamrasni S, Khosravi F, Trentin GA, Martirosyan A, Hakem A, Hakem R, Jurisica I, Penn LZ. Dysregulation of the mevalonate pathway promotes transformation. Proc Natl Acad Sci USA. 2010;107 (34:15051–15056. - PMC - PubMed

[7] Clendening JW, Penn LZ. Targeting tumor cell metabolism with statins. Oncogene. 2012;31 (48:4967–4978. - PubMed

[8] Clendening JW, Penn LZ. Targeting tumor cell metabolism with statins. Oncogene. 2012;31 (48:4967–4978. - PubMed

[9] Coimbra M, Banciu M, Fens MH, de Smet L, Cabaj M, Metselaar JM, Storm G, Schiffelers RM. Liposomal pravastatin inhibits tumor growth by targeting cancer-related inflammation. J Control Release. 2010;148 (3:303–310. - PubMed

[10] Coimbra M, Banciu M, Fens MH, de Smet L, Cabaj M, Metselaar JM, Storm G, Schiffelers RM. Liposomal pravastatin inhibits tumor growth by targeting cancer-related inflammation. J Control Release. 2010;148 (3:303–310. - PubMed

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Statin use is not associated with reduced risk of skin cancer: a meta-analysis

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Statin use is not associated with reduced risk of skin cancer: a meta-analysis

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