Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2014 Apr;34(4):473-6.
doi: 10.1007/s00296-013-2924-8. Epub 2013 Dec 24.

Common variants of a urate-associated gene LRP2 are not associated with gout susceptibility

Akiyoshi Nakayama  1 , Hirotaka Matsuo, Toru Shimizu, Yuzo Takada, Takahiro Nakamura, Seiko Shimizu, Toshinori Chiba, Masayuki Sakiyama, Mariko Naito, Emi Morita, Kimiyoshi Ichida, Nariyoshi Shinomiya
Affiliations
Multicenter Study

Common variants of a urate-associated gene LRP2 are not associated with gout susceptibility

Akiyoshi Nakayama et al. Rheumatol Int. 2014 Apr.

Abstract

A recent genome-wide association study revealed that there is an association between serum uric acid (SUA) levels and rs2544390, a common variant in low-density lipoprotein-related protein 2 (LRP2/Megalin) gene. Two other variants of LRP2, rs2229268 and rs3755166, are also found to have associations with dyslipidemia and Alzheimer's disease, respectively, which also could have a relationship with SUA in human. Although no studies report that LRP2 transports urate, LRP2 is a multi-ligand receptor and expresses in many tissues including kidney, suggesting a direct and/or indirect relationship with gout. In the present study, we investigated the association between gout and these variants of LRP2 with 741 clinically diagnosed male gout patients and 1,302 controls. As a result, the three common LRP2 variants, rs2544390, rs2229268 and rs3755166, showed no association with gout (P = 0.76, 0.55, and 0.22, respectively). Our study is the first to reveal that an SUA-related gene LRP2 is not involved in gout susceptibility.

PubMed Disclaimer

References

    1. Kamatani Y, Matsuda K, Okada Y, Kubo M, Hosono N, Daigo Y, Nakamura Y, Kamatani N. Genome-wide association study of hematological and biochemical traits in a Japanese population. Nat Genet. 2010;42(3):210–215. doi: 10.1038/ng.531. - DOI - PubMed
    1. Mii A, Nakajima T, Fujita Y, Iino Y, Kamimura K, Bujo H, Saito Y, Emi M, Katayama Y. Genetic association of low-density lipoprotein receptor-related protein 2 (LRP2) with plasma lipid levels. J Atheroscler Thromb. 2007;14(6):310–316. doi: 10.5551/jat.E494. - DOI - PubMed
    1. Wang LL, Pan XL, Wang Y, Tang HD, Deng YL, Ren RJ, Xu W, Ma JF, Wang G, Chen SD. A single nucleotide polymorphism in LRP2 is associated with susceptibility to Alzheimer’s disease in the Chinese population. Clin Chim Acta. 2011;412(3–4):268–270. doi: 10.1016/j.cca.2010.10.015. - DOI - PubMed
    1. Wallace SL, Robinson H, Masi AT, Decker JL, McCarty DJ, Yu TF. Preliminary criteria for the classification of the acute arthritis of primary gout. Arthritis Rheum. 1977;20(3):895–900. doi: 10.1002/art.1780200320. - DOI - PubMed
    1. Hamajima N, J-MICC Study Group The Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study to detect gene–environment interactions for cancer. Asian Pac J Cancer Prev. 2007;8(2):317–323. - PubMed

Publication types

Substances