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. 2015 Dec;45(12):4015-25.
doi: 10.1007/s10803-013-2016-3.

Maternal Infection During Pregnancy and Autism Spectrum Disorders

Ousseny Zerbo  1 , Yinge Qian  2 , Cathleen Yoshida  2 , Judith K Grether  3 , Judy Van de Water  4   5   6 , Lisa A Croen  2
Affiliations

Maternal Infection During Pregnancy and Autism Spectrum Disorders

Ousseny Zerbo et al. J Autism Dev Disord. 2015 Dec.

Abstract

We conducted a nested case-control study including 407 cases and 2,075 frequency matched controls to investigate the association between maternal infections during pregnancy and risk of autism spectrum disorders (ASD). Cases, controls, and maternal infections were ascertained from Kaiser Permanente Northern California clinical databases. No overall association between diagnoses of any maternal infection during pregnancy and ASD was observed [adjusted odds ratio (ORadj) = 1.15, 95 % confidence interval (CI) 0.92-1.43]. However, women with infections diagnosed during a hospital admission (ORadj = 1.48, 95 % CI 1.07-2.04), particularly bacterial infections (ORadj = 1.58, 95 % CI 1.06-2.37), were at increased risk of delivering a child with ASD. Multiple infections during pregnancy were associated with ASD (ORadj = 1.36, 95 % CI 1.05-1.78).

Keywords: Autism spectrum disorder; Maternal infection; Pregnancy.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors declare that they have no conflict of interest.

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