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. 2013 Dec;74 Suppl 1(Suppl 1):4-16.
doi: 10.1038/pr.2013.203.

Estimates of neonatal morbidities and disabilities at regional and global levels for 2010: introduction, methods overview, and relevant findings from the Global Burden of Disease study

Hannah Blencowe  1 , Theo Vos  2 , Anne C C Lee  3 , Rachel Philips  4 , Rafael Lozano  5 , Miriam R Alvarado  5 , Simon Cousens  1 , Joy E Lawn  6
Affiliations
Free PMC article

Estimates of neonatal morbidities and disabilities at regional and global levels for 2010: introduction, methods overview, and relevant findings from the Global Burden of Disease study

Hannah Blencowe et al. Pediatr Res. 2013 Dec.
Free PMC article

Abstract

Background: Neonatal mortality and morbidity are increasingly recognized as important globally, but detailed estimates of neonatal morbidity from conditions and long-term consequences are yet to be published.

Methods: We describe the general methods for systematic reviews, meta-analyses, and modeling used in this supplement, highlighting differences from the Global Burden of Disease (GBD2010) inputs and methods. For five conditions (preterm birth, retinopathy of prematurity, intrapartum-related conditions, neonatal infections, and neonatal jaundice), a standard three-step compartmental model was applied to estimate--by region, for 2010--the numbers of (i) affected births by sex, (ii) postneonatal survivors, and (iii) impaired postneonatal survivors. For conditions included in GBD2010 analyses (preterm birth and intrapartum-related conditions), impairment at all ages was estimated, and disability weights were applied to estimate years lived with disability (YLD) and summed with years of life lost (YLL) to calculate disability-adjusted life years (DALYs).

Results: GBD2010 estimated neonatal conditions (preterm birth, intrapartum-related, neonatal sepsis, and "other neonatal") to be responsible for 202 million DALYs or 8.1% (7.3-9.0%) of the worldwide total. Mortality contributed 95% of the DALYs, and the estimated 26% reduction in neonatal condition DALYs since 1990 is primarily due to a 44% reduction in neonatal mortality rate due to these conditions, counterbalanced by increased numbers of babies born (17%). Impairment following neonatal conditions remained stable globally and is therefore relatively more important, especially in high- and middle-income countries. Crucial data gaps were identified.

Conclusion: These results confirm neonatal conditions as a significant burden, reemphasizing the need to reduce deaths further, to count the linked 2.6 million stillbirths, and to better measure and address their long-term effects.

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Figures

Figure 1
Figure 1
Progress toward Millennium Development Goal 4 for child survival showing progress for 193 countries based on estimates by the United Nations (UN) and by the Institute for Health Metrics and Evaluation (IHME).
Figure 2
Figure 2
Overview of parameters required and methods for estimation of the global burden of neonatal conditions. aThe analyses for years lived with disability and disability-adjusted life years were undertaken in the Global Burden of Disease study for preterm birth and intrapartum-related conditions and will be detailed in the articles in the supplement.
Figure 3
Figure 3
Regional groups used in the Global Burden of Disease (GBD) 2010 estimation. Regional groupings based on super-GBD regions, which condenses the 21 GBD regions into 7 (19).
Figure 4
Figure 4
Global Burden of Disease (GBD2010) estimated distribution of the 2.5 billion disability-adjusted life years for 2010 for all age groups.
See this image and copyright information in PMC

References

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