Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014;58(3):1800-1.
doi: 10.1128/AAC.02263-13. Epub 2013 Dec 23.

In vitro activity of nemonoxacin, a novel nonfluorinated quinolone antibiotic, against Chlamydia trachomatis and Chlamydia pneumoniae

Kobkul Chotikanatis  1 , Stephan A Kohlhoff, Margaret R Hammerschlag
Affiliations

In vitro activity of nemonoxacin, a novel nonfluorinated quinolone antibiotic, against Chlamydia trachomatis and Chlamydia pneumoniae

Kobkul Chotikanatis et al. Antimicrob Agents Chemother. 2014.

Abstract

The in vitro activities of nemonoxacin, levofloxacin, azithromycin, and doxycycline were tested against 10 isolates each of Chlamydia trachomatis and Chlamydia pneumoniae. The MICs at which 90% of the isolates of both C. trachomatis and C. pneumoniae were inhibited (MIC90s) were 0.06 μg/ml (range, 0.03 to 0.13 μg/ml). The minimal bactericidal concentrations at which 90% of the isolates were killed by nemonoxacin (MBC90s) were 0.06 μg/ml for C. trachomatis (range, 0.03 to 0.125 μg/ml) and 0.25 for C. pneumoniae (range, 0.015 to 0.5 μg/ml).

PubMed Disclaimer

References

    1. Centers for Disease Control and Prevention 2012. Sexually transmitted disease surveillance 2011 Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, GA: http://www.cdc.gov/std/stats11/default.htm
    1. Hammerschlag MR, Kohlhoff SA, Apfalter PM. 2010. Chlamydia (Chlamydophila) pneumoniae, p 2467–2475 In Mandell GL, Bennett JE, Dolin R. (ed), Mandell, Douglas and Bennett's principles and practice of infectious diseases, 7th ed, vol 1 Elsevier, Philadelphia, PA
    1. Hooper DC, Strahilevitz J. 2010. Quinolones: anti-infective therapy, p 487–490 In Mandell GL, Bennett JE, Dolin R. (ed), Mandell, Douglas and Bennett's principles and practice of infectious diseases, 7th ed, vol 1 Elsevier, Philadelphia, PA
    1. Pan XS, Ambler J, Mehtar S, Fisher LM. 1996. Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 40:2321–2326 - PMC - PubMed
    1. Kings CR, Lin L, Leunk R. 2008. In vitro resistance development to nemonoxacin for Streptococcus pneumoniae, abstr C1-1971, p 131–132. Abstr. 48th Annu. Intersci. Conf. Antimicrob. Agents. Chemother. (ICAAC)-Infect. Dis. Soc. Am. (IDSA) 46th Annu Meet American Society for Microbiology and Infectious Diseases Society of America, Washington, DC

MeSH terms

LinkOut - more resources