Antibiotic prophylaxis for hip fracture surgery: three-dose cefuroxime versus single-dose gentamicin and amoxicillin

Abstract

Purpose: To compare a 3-dose cefuroxime regimen with a single-dose gentamicin and amoxicillin regimen as antibiotic prophylaxis for hip hemiarthroplasty in terms of microbiological outcome.

Methods: Records of 2 matched groups of patients who underwent hip hemiarthroplasty for femoral neck fractures were reviewed. 29 men and 84 women (mean age, 82 years) who received a 3-dose cefuroxime regimen in 2006 were compared with 23 men and 84 women (mean age, 83 years) who received a single-dose gentamicin and amoxicillin regimen in 2008. Patient demographics, antibiotics prescribed in the peri- and immediate postoperative period, microbiological evidence for Clostridium difficile 'infection', length of hospital stay, mortality, as well as biochemical and haematological findings were reviewed.

Results: The 3-dose cefuroxime group was significantly higher in terms of the mean length of hospital stay (17 vs. 13 days, p=0.043) and the percentage of patients receiving postoperative antibiotics (88% vs. 68%, p<0.001) and having C difficile 'infection' (6% vs. 0%, p=0.016). If patients with C difficile 'infection' were excluded, there was no significant difference in the length of hospital stay.

Conclusion: The single-dose gentamicin and amoxicillin regimen was associated with a lower C difficile 'infection' rate.

Keywords: Clostidium difficile; antibiotic prophylaxis; diarrhea; hip fractures.