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Editorial
. 2014 Jan;16(1):4-6.
doi: 10.1093/neuonc/not233.

Getting more out of radiation therapy in glioblastoma

Brandyn A Castro  1 , Manish K Aghi
Affiliations
Editorial

Getting more out of radiation therapy in glioblastoma

Brandyn A Castro et al. Neuro Oncol. 2014 Jan.
No abstract available

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Figures

Fig. 1.
Fig. 1.
Dual receptors lead to dual functions of SDF-1 (CXCL12) in glioblastoma vasculogenesis after radiation therapy. Irradiated tumor cells secrete SDF-1, which binds CXCR4 expressed by marrow-derived myelomonocytes and CXCR7 expressed by marrow-derived endothelial precursors, which together participate in vasculogenesis.
See this image and copyright information in PMC

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References

    1. Kioi M, Vogel H, Schultz G, Hoffman RM, Harsh GR, Brown JM. Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J Clin Invest. 120:694–705. - PMC - PubMed
    1. Liu SC, Alomran R, Chernikova SB, Lartey F, Stafford J, Jang T, Merchant M, Zboralski D, Zöllner S, Kruschinski A, Klussmann S, Recht L, Brown JM. Blockade of SDF-1 after irradiation inhibits tumor recurrences of autochthonous brain tumors in rats. Neuro-Oncology. 2014;16:21–28. 2013. - PMC - PubMed
    1. Aghi M, Cohen KS, Klein RJ, Scadden DT, Chiocca EA. Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer Res. 2006;66:9054–9064. - PubMed
    1. Balabanian K, Lagane B, Infantino S, et al. The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. J Biol Chem. 2005;280:35760–35766. - PubMed
    1. Kalatskaya I, Berchiche YA, Gravel S, Limberg BJ, Rosenbaum JS, Heveker N. AMD3100 is a CXCR7 ligand with allosteric agonist properties. Mol Pharmacol. 2009;75:1240–1247. - PubMed

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