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Comment
. 2014 Jan 7;111(1):7-8.
doi: 10.1073/pnas.1321881111. Epub 2013 Dec 23.

Mitochondria impact brain function and cognition

Martin Picard  1 , Bruce S McEwen
Affiliations
Comment

Mitochondria impact brain function and cognition

Martin Picard et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Schematic representation of presynaptic mitochondria in the mammalian brain and their effect on synaptic remodeling. Donut-shaped mitochondria are negative neuromodulators associated with smaller active zones and fewer docked vesicles in the dorsolateral prefrontal cortex (dlPFC) of monkeys and correlated with poor delayed response memory. (Inset) Donut mitochondria form by curvature and self-fusion of preexisting mitochondrial tubules (10, 11).
See this image and copyright information in PMC

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References

    1. McEwen BS. Stress, sex, and neural adaptation to a changing environment: Mechanisms of neuronal remodeling. Ann N Y Acad Sci. 2010;1204(Suppl):E38–E59. - PMC - PubMed
    1. Duman RS, Monteggia LM. A neurotrophic model for stress-related mood disorders. Biol Psychiatry. 2006;59(12):1116–1127. - PubMed
    1. McEwen BS. Brain on stress: How the social environment gets under the skin. Proc Natl Acad Sci USA. 2012;109(Suppl 2):17180–17185. - PMC - PubMed
    1. Hara Y, Yuk F, Puri R, Janssen WGM, Rapp PR, Morrison JH. Presynaptic mitochondrial morphology in monkey prefrontal cortex correlates with working memory and is improved with estrogen treatment. Proc Natl Acad Sci USA. 2014;111:486–491. - PMC - PubMed
    1. Wallace DC. Colloquium paper: Bioenergetics, the origins of complexity, and the ascent of man. Proc Natl Acad Sci USA. 2010;107(Suppl 2):8947–8953. - PMC - PubMed

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