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. 2011 Apr 19:3:27-33.
doi: 10.2147/BCTT.S17892. eCollection 2011.

Estrogen receptor (ER) and progesterone receptor (PgR) in breast cancer of Indian women

Amit V Patil  1 , Rahul S Bhamre  2 , Rajeev Singhai  3 , Mukund B Tayade  4 , Vinayak W Patil  3
Affiliations

Estrogen receptor (ER) and progesterone receptor (PgR) in breast cancer of Indian women

Amit V Patil et al. Breast Cancer (Dove Med Press). .

Retraction in

  • Retraction.
    [No authors listed] [No authors listed] Breast Cancer (Dove Med Press). 2012 Mar 8;4:33. doi: 10.2147/BCTT.S31163. eCollection 2012. Breast Cancer (Dove Med Press). 2012. PMID: 24367192 Free PMC article. No abstract available.

Abstract

Objective: To determine the expressions and relationship between estrogen receptors (ERs) and progesterone receptors (PgRs) in breast cancer in Indian women.

Participants: Surgically removed breast cancer tissues were collected from Grant Medical College and Sir JJ Group of Hospitals, Mumbai, India, taking (n = 300) cases of infiltrating duct cancer of Indian women after radical mastectomy and lumpectomy; the age- and menopausal-related subgroups satisfied this requirement.

Measurements: Statistical significance was calculated by the likelihood ratio test; relative risk served to check for significant differences. Relapse-free interval probabilities were calculated according to Kaplan and Meier, with Cox-Mantel test comparing survival functions and P values.

Results: We observed that only in middle-aged postmenopausal patients bearing pT2 tumors were ER and PgR receptors shown to have a prognostic significance with the lowest tested cutoff value being 5 fmol/mg.

Conclusion: Immunohistochemistry analysis has been shown to be a prognostic factor for patients with breast cancer; the major aim of determining the ER receptor status is to assess predictive response to hormonal therapy.

Keywords: hormone receptors; immunohistochemistry; prognostic cancer tissue biomarkers; steroid receptors.

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Figures

Figure 1
Figure 1
Immunostaining of infiltrating duct breast cancer of Indian women, (×400 objective magnification): dark brown nuclear positive staining for estrogen receptor (A) and dark brown nuclear positive staining for progesterone receptor (B).
Figure 2
Figure 2
Steroid hormone receptor ER and PgR status-related disease-free probability (p) of node-negative postmenopausal middle-aged breast cancer patients with pT2 tumors. Abbreviations: ER, estrogen receptor; PgR, progesterone receptor.
Figure 3
Figure 3
Relapse-free probability of survival in node-negative breast cancer patients according to the steroid hormone receptor phenotypes. Abbreviations: ER, estrogen receptor; PgR, progesterone receptor; t, time.
Figure 4
Figure 4
Observed breast cancer in Indian women recurrence relative to ER and PgR phenotypes. Abbreviations: ER, estrogen receptor; PgR, progesterone receptor.
See this image and copyright information in PMC

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