Immune therapeutic strategies in chronic hepatitis B virus infection: virus or inflammation control?

Antonio Bertoletti¹, Adam J Gehring²

Affiliations

¹ Program in Emerging Viral Diseases, Duke-NUS Graduate Medical School, Singapore ; Viral Hepatitis Unit, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (AStar), Singapore.
² Molecular Microbiology and Immunology Department, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America.

PMID: 24367255
PMCID: PMC3868509
DOI: 10.1371/journal.ppat.1003784

Immune therapeutic strategies in chronic hepatitis B virus infection: virus or inflammation control?

Antonio Bertoletti et al. PLoS Pathog. 2013.

. 2013;9(12):e1003784.

doi: 10.1371/journal.ppat.1003784. Epub 2013 Dec 19.

Authors

Antonio Bertoletti¹, Adam J Gehring²

Affiliations

¹ Program in Emerging Viral Diseases, Duke-NUS Graduate Medical School, Singapore ; Viral Hepatitis Unit, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (AStar), Singapore.
² Molecular Microbiology and Immunology Department, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America.

PMID: 24367255
PMCID: PMC3868509
DOI: 10.1371/journal.ppat.1003784

No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

**Figure 1. Different immune-based therapeutic strategies aiming to increase HBV control.**

**Figure 2. Schematic representation of the potential ability of HBV-loaded monocytes to stimulate HBV-specific T cells trough TLR or anti-CD40 agonists .**
MN = monocytes, DC = dendritic cells.

See this image and copyright information in PMC

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References

1. Bertoletti A, Ferrari C (2012) Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection. Gut 61: 1754–1764. - PubMed
1. Kamatani Y, Wattanapokayakit S, Ochi H, Kawaguchi T, Takahashi A, et al. (2009) A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nat Genet 41: 591–595. - PubMed
1. Asabe S, Wieland SF, Chattopadhyay PK, Roederer M, Engle RE, et al. (2009) The size of the viral inoculum contributes to the outcome of hepatitis B virus infection. J Virol 83: 9652–9662. - PMC - PubMed
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Immune therapeutic strategies in chronic hepatitis B virus infection: virus or inflammation control?

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Immune therapeutic strategies in chronic hepatitis B virus infection: virus or inflammation control?

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Conflict of interest statement

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