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Review
. 2013;9(12):e1003793.
doi: 10.1371/journal.ppat.1003793. Epub 2013 Dec 19.

Burning down the house: cellular actions during pyroptosis

Christopher N LaRock  1 , Brad T Cookson  2
Affiliations
Review

Burning down the house: cellular actions during pyroptosis

Christopher N LaRock et al. PLoS Pathog. 2013.
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Effector mechanisms of pyroptosis.
(A) Caspase-1 activation in response to microbial infection (black ovals) initiates numerous pathways that promote death or recovery of the cell, directly combat pathogen infection, or signal to other cells. (B) The proinflammatory cytokines IL-1β and IL-18 are cleaved and secreted, and HMGB1, IL-1α, FGF2, and numerous damage-associated molecular patterns are also released. (C) Caspase-1 can also initiate programmed cell death, eliminating a niche for intracellular pathogens while releasing both pathogen and proinflammatory signals. (D) Intracellular pathogens and antimicrobial factors that kill extracellular bacteria can be released by lysosomal exocytosis, also promoting adaptive immune responses through cross-priming. (E) Caspase-1 promotes cellular integrity by removing microbes or damaged organelles by stimulating autophagy, enhanced lysosome activity, induction of lipid metabolism, and exocytosis of damaged or infected organelles. (F) Proinflammatory signals released by lysis, exocytosis, and other secretory pathways recruit and activate immune cells (blue; clockwise from top: neutrophils, lymphocytes, macrophages/dendritic cells). The specific responses of a cell vary depending on the kinetics and magnitude of caspase-1 stimulation, the activating stimulus, and cell type.
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