Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013;9(12):e1003793.
doi: 10.1371/journal.ppat.1003793. Epub 2013 Dec 19.

Burning down the house: cellular actions during pyroptosis

Christopher N LaRock  1 , Brad T Cookson  2
Affiliations
Review

Burning down the house: cellular actions during pyroptosis

Christopher N LaRock et al. PLoS Pathog. 2013.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Effector mechanisms of pyroptosis.
(A) Caspase-1 activation in response to microbial infection (black ovals) initiates numerous pathways that promote death or recovery of the cell, directly combat pathogen infection, or signal to other cells. (B) The proinflammatory cytokines IL-1β and IL-18 are cleaved and secreted, and HMGB1, IL-1α, FGF2, and numerous damage-associated molecular patterns are also released. (C) Caspase-1 can also initiate programmed cell death, eliminating a niche for intracellular pathogens while releasing both pathogen and proinflammatory signals. (D) Intracellular pathogens and antimicrobial factors that kill extracellular bacteria can be released by lysosomal exocytosis, also promoting adaptive immune responses through cross-priming. (E) Caspase-1 promotes cellular integrity by removing microbes or damaged organelles by stimulating autophagy, enhanced lysosome activity, induction of lipid metabolism, and exocytosis of damaged or infected organelles. (F) Proinflammatory signals released by lysis, exocytosis, and other secretory pathways recruit and activate immune cells (blue; clockwise from top: neutrophils, lymphocytes, macrophages/dendritic cells). The specific responses of a cell vary depending on the kinetics and magnitude of caspase-1 stimulation, the activating stimulus, and cell type.
See this image and copyright information in PMC

References

    1. Netea MG, Simon A, van de Veerdonk FLV, Kullberg BJ, Van der Meer J, et al. (2010) IL-1beta Processing in Host Defense: Beyond the Inflammasomes. PLoS Pathog 6: e1000661 doi:10.1371/journal.ppat.1000661 - DOI - PMC - PubMed
    1. Miao EA, Leaf IA, Treuting PM, Mao DP, Dors M, et al. (2010) Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol 11: 1136–1142. - PMC - PubMed
    1. Cookson BT, Brennan MA (2001) Pro-inflammatory programmed cell death. Trends Microbiol 9: 113–114. - PubMed
    1. Lamkanfi M, Kanneganti T-D, Van Damme P, Berghe TV, Vanoverberghe I, et al. (2008) Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes. Mol Cell Proteomics 7: 2350–2363. - PMC - PubMed
    1. Shao W, Yeretssian G, Doiron K, Hussain SN, Saleh M (2007) The caspase-1 digestome identifies the glycolysis pathway as a target during Infection and Septic Shock. J Biol Chem 282: 36321–36329. - PubMed

Publication types

LinkOut - more resources