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. 2013 Dec 19;8(12):e83605.
doi: 10.1371/journal.pone.0083605. eCollection 2013.

Space-time clustering characteristics of tuberculosis in China, 2005-2011

Fei Zhao  1 , Shiming Cheng  1 , Guangxue He  1 , Fei Huang  1 , Hui Zhang  1 , Biao Xu  2 , Tonderayi C Murimwa  3 , Jun Cheng  1 , Dongmei Hu  1 , Lixia Wang  1
Affiliations

Space-time clustering characteristics of tuberculosis in China, 2005-2011

Fei Zhao et al. PLoS One. .

Abstract

Objectives: China is one of the 22 tuberculosis (TB) high-burden countries in the world. As TB is a major public health problem in China, spatial analysis could be applied to detect geographic distribution of TB clusters for targeted intervention on TB epidemics.

Methods: Spatial analysis was applied for detecting TB clusters on county-based TB notification data in the national notifiable infectious disease case reporting surveillance system from 2005 to 2011. Two indicators of TB epidemic were used including new sputum smear-positive (SS+) notification rate and total TB notification rate. Global Moran's I by ArcGIS was used to assess whether TB clustering and its trend were significant. SaTScan software that used the retrospective space-time analysis and Possion probability model was utilized to identify geographic areas and time period of potential clusters with notification rates on county-level from 2005 to 2011.

Results: Two indicators of TB notification had presented significant spatial autocorrelation globally each year (p<0.01). Global Moran's I of total TB notification rate had positive trend as time went by (t=6.87, p<0.01). The most likely clusters of two indicators had similar spatial distribution and size in the south-central regions of China from 2006 to 2008, and the secondary clusters in two regions: northeastern China and western China. Besides, the secondary clusters of total TB notification rate had two more large clustering centers in Inner Mongolia, Gansu and Qinghai provinces and several smaller clusters in Shanxi, Henan, Hebei and Jiangsu provinces.

Conclusion: The total TB notification cases clustered significantly in some special areas each year and the clusters trended to aggregate with time. The most-likely and secondary clusters that overlapped among two TB indicators had higher TB burden and risks of TB transmission. These were the focused geographic areas where TB control efforts should be prioritized.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Trends of Moran’s I on two TB notification rates in China from 2005 to 2011.
Figure 2
Figure 2. SaTScan analysis on new SS+ notification rate (A) and total TB notification rate (B) from 2005 to 2011.
See this image and copyright information in PMC

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