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. 2013 Dec 19;8(12):e84542.
doi: 10.1371/journal.pone.0084542. eCollection 2013.

History of having a macrosomic infant and the risk of diabetes: the Japan public health center-based prospective diabetes study

Yusuke Kabeya  1 , Atsushi Goto  2 , Masayuki Kato  3 , Yoshihiko Takahashi  4 , Yumi Matsushita  3 , Manami Inoue  5 , Tetsuya Mizoue  6 , Shoichiro Tsugane  7 , Takashi Kadowaki  8 , Mitsuhiko Noda  2
Affiliations

History of having a macrosomic infant and the risk of diabetes: the Japan public health center-based prospective diabetes study

Yusuke Kabeya et al. PLoS One. .

Abstract

Objective: The aim of the present study was to test a hypothesis that a history of having a macrosomic infant (≥ 4000 g) is associated with the risk of diabetes.

Methods: Data on the Japan Public Health Center-based Prospective diabetes cohort were analyzed, which is a population-based cohort study on diabetes. The survey of diabetes was performed at baseline and at the 5-year follow-up. A history of having a macrosomic infant was assessed using a self-administered questionnaire. A cross-sectional analysis was performed among 12,153 women who participated in the 5-year survey of the cohort. Logistic regression was used to examine the relationship between a history of having a macrosomic infant and the presence of diabetes. A longitudinal analysis was also conducted among 7,300 women without diabetes who participated in the baseline survey. Logistic regression was used to investigate the relationship between a history of having a macrosomic infant and the incidence of diabetes between the baseline survey and the 5-year survey.

Results: In the cross-sectional analysis, parous women with a positive history were more likely to have diabetes in relation to parous women without (OR = 1.44, 95% CI = 1.13-1.83). The longitudinal analysis showed a modest but non-significant increased risk of developing diabetes among women with a positive history (OR = 1.24, 95% CI = 0.80-1.94).

Conclusions: An increased risk of diabetes was implied among women with a history of having a macrosomic infant although the longitudinal analysis showed a non-significant increased risk.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Study flow chart.
See this image and copyright information in PMC

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