Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013;4(6):154.
doi: 10.1186/scrt384.

Modeling human brain development with cerebral organoids

Luca Muzio, G Giacomo Consalez
Comment

Modeling human brain development with cerebral organoids

Luca Muzio et al. Stem Cell Res Ther. 2013.

Abstract

The recent discovery of a new three-dimensional culture system for the derivation of cerebral organoids from human induced pluripotent stem cells provides developmental neurobiologists with the first example of a three-dimensional framework for the study of human brain development. This innovative approach permits the in vitro assembly of a human embryonic brain rudiment that recapitulates the developing human cerebrum. Organoids contain progenitor populations that develop to yield mature cortical neuron subtypes, potentially allowing investigators to study complex brain diseases that lack appropriate animal models.

PubMed Disclaimer

Comment on

References

    1. Lancaster MA, Renner M, Martin CA, Wenzel D, Bicknell LS, Hurles ME, Homfray T, Penninger JM, Jackson AP, Knoblich JA. Cerebral organoids model human brain development and microcephaly. Nature. 2013;4:373–379. doi: 10.1038/nature12517. - DOI - PMC - PubMed
    1. Soldner F, Jaenisch R. Medicine. iPSC disease modeling. Science. 2012;4:1155–1156. doi: 10.1126/science.1227682. - DOI - PubMed
    1. Soldner F, Hockemeyer D, Beard C, Gao Q, Bell GW, Cook EG, Hargus G, Blak A, Cooper O, Mitalipova M, Isacson O, Jaenisch R. Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell. 2009;4:964–977. doi: 10.1016/j.cell.2009.02.013. - DOI - PMC - PubMed
    1. Wang X, Tsai JW, LaMonica B, Kriegstein AR. A new subtype of progenitor cell in the mouse embryonic neocortex. Nat Neurosci. 2011;4:555–561. doi: 10.1038/nn.2807. - DOI - PMC - PubMed
    1. Bond J, Roberts E, Springell K, Lizarraga SB, Scott S, Higgins J, Hampshire DJ, Morrison EE, Leal GF, Silva EO, Costa SM, Baralle D, Raponi M, Karbani G, Rashid Y, Jafri H, Bennett C, Corry P, Walsh CA, Woods CG. A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size. Nat Genet. 2005;4:353–355. doi: 10.1038/ng1539. - DOI - PubMed