Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Mar;94(2):105-10.
doi: 10.1016/j.tube.2013.11.003. Epub 2013 Dec 1.

A review of preclinical animal models utilised for TB vaccine evaluation in the context of recent human efficacy data

Helen McShane  1 , Ann Williams  2
Affiliations
Review

A review of preclinical animal models utilised for TB vaccine evaluation in the context of recent human efficacy data

Helen McShane et al. Tuberculosis (Edinb). 2014 Mar.

Abstract

There is an urgent need for an improved TB vaccine. Vaccine development is hindered by the lack of immune correlates and uncertain predictive value of preclinical animal models. As data become available from human efficacy trials, there is an opportunity to evaluate the predictive value of the criteria used to select candidate vaccines. Here we review the efficacy in animal models of the MVA85A candidate vaccine in light of recent human efficacy data and propose refinements to the preclinical models with the aim of increasing their predictive value for human efficacy.

Keywords: Clinical; Efficacy; MVA85A; Pre-clinical; Vaccine.

PubMed Disclaimer

Comment in

  • Letter to the editor.
    Orme I. Orme I. Tuberculosis (Edinb). 2014 Dec;94(6):717. doi: 10.1016/j.tube.2014.08.004. Epub 2014 Sep 19. Tuberculosis (Edinb). 2014. PMID: 25293999 No abstract available.

References

    1. Boehme C.C., Nabeta P., Hillemann D., Nicol M.P., Shenai S., Krapp F., Allen J., Tahirli R., Blakemore R., Rustomjee R., Milovic A., Jones M., O'Brien S.M., Persing D.H., Ruesch-Gerdes S., Gotuzzo E., Rodrigues C., Alland D., Perkins M.D. Rapid molecular detection of tuberculosis and rifampin resistance. N Engl J Med. 2010;363:1005–1015. - PMC - PubMed
    1. Anon . December 31, 2012. FDA approves first drug to treat multi-drug resistant tuberculosis2012.http://wwwfdagov/NewsEvents/Newsroom/PressAnnouncements/2012/defaulthtm Available from:
    1. Brennan M.J., Thole J. Tuberculosis vaccines: a strategic blueprint for the next decade. Tuberculosis (Edinb) 2012;92(Suppl. 1):S6–S13. - PubMed
    1. Ordway D., Palanisamy G., Henao-Tamayo M., Smith E.E., Shanley C., Orme I.M., Basaraba R.J. The cellular immune response to Mycobacterium tuberculosis infection in the guinea pig. J Immunol. 2007;179:2532–2541. - PubMed
    1. Shang S., Harton M., Tamayo M.H., Shanley C., Palanisamy G.S., Caraway M., Chan E.D., Basaraba R.J., Orme I.M., Ordway D.J. Increased Foxp3 expression in guinea pigs infected with W-Beijing strains of M. tuberculosis. Tuberculosis (Edinb) 2011;91:378–385. - PMC - PubMed

Publication types