Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 May;55(5):1121-5.
doi: 10.1128/iai.55.5.1121-1125.1987.

Augmentation of endotoxin fever by recombinant human beta interferon in rabbits

H Kawasaki, M Moriyama, A Tanaka

Augmentation of endotoxin fever by recombinant human beta interferon in rabbits

H Kawasaki et al. Infect Immun. 1987 May.

Abstract

Nonpyrogenic amounts of endotoxin (0.1 to 1 ng/kg), hardly detectable by conventional Limulus amoebocyte lysate tests, could produce a fever of around 1 degree C when injected with a nonpyrogenic dose (6 X 10(5) U/kg) of recombinant human beta interferon (IFN-beta) in rabbits. Release of endogenous IFN and tumor necrosis factor by endotoxin was also dramatically increased by recombinant human IFN-beta, and their levels in the blood were closely correlated with the increase of body temperature. These data suggest, if the synergism between IFN and endotoxin also operates in the homologous system (human IFN-human cells), that contaminating endotoxin in IFNs, even if not detectable by Limulus amoebocyte lysate test, can contribute to IFN fever to a considerable extent in humans.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Infect Dis. 1979 Oct;140(4):560-3 - PubMed
    1. J Biol Response Mod. 1984 Dec;3(6):580-98 - PubMed
    1. Int J Cancer. 1985 Sep 15;36(3):395-400 - PubMed
    1. Gan. 1983 Oct;74(5):737-42 - PubMed
    1. Clin Pharmacol Ther. 1984 May;35(5):722-7 - PubMed