Comparative Study
doi: 10.1159/000234266.
Some studies on human pulmonary mast cells obtained by bronchoalveolar lavage and by enzymic dissociation of whole lung tissue
- PMID: 2437052
- DOI: 10.1159/000234266
Item in Clipboard
Comparative Study
Some studies on human pulmonary mast cells obtained by bronchoalveolar lavage and by enzymic dissociation of whole lung tissue
Int Arch Allergy Appl Immunol.
1987.
Abstract
Human pulmonary mast cells were obtained by bronchoalveolar lavage (BAL) and by enzymic dissociation of whole lung. The cells released histamine on immunological stimulation or on exposure to a hyperosmolar environment. Cell suspensions similarly released newly generated products of arachidonic acid metabolism. Increased numbers of mast cells were recovered by BAL of asthmatic subjects and patients suffering from sarcoidosis and these cells were hyperresponsive to immunological challenge. Mast cells recovered by BAL and enzymic dissociation were differentially inhibited by antiasthmatic drugs. These data emphasize the potential role of BAL mast cells in pulmonary diseases of diverse origin.
Similar articles
-
Some further properties of human pulmonary mast cells recovered by bronchoalveolar lavage and enzymic dispersion of lung tissue.Agents Actions. 1987 Apr;20(3-4):213-5. doi: 10.1007/BF02074672. Agents Actions. 1987. PMID: 2440274
-
Characterization of primate bronchoalveolar mast cells. I. IgE-dependent release of histamine, leukotrienes, and prostaglandins.J Immunol. 1986 Dec 15;137(12):3933-40. J Immunol. 1986. PMID: 2431048
-
Characterization of primate bronchoalveolar mast cells. II. Inhibition of histamine, LTC4, and PGD2 release from primate bronchoalveolar mast cells and a comparison with rat peritoneal mast cells.J Immunol. 1986 Dec 15;137(12):3941-5. J Immunol. 1986. PMID: 2431049
-
Mediator release from human basophils and mast cells from lung and intestinal mucosa.Int Arch Allergy Appl Immunol. 1985;77(1-2):130-6. doi: 10.1159/000233767. Int Arch Allergy Appl Immunol. 1985. PMID: 2409011 Review. No abstract available.
-
Relationship between mediator release from human lung mast cells in vitro and in vivo.Int Arch Allergy Appl Immunol. 1985;77(1-2):47-56. doi: 10.1159/000233752. Int Arch Allergy Appl Immunol. 1985. PMID: 2409026 Review.
Cited by
-
Mediator release from human lung mast cell subtypes in chronic bronchitis and emphysema.Agents Actions. 1989 Apr;27(1-2):97-100. doi: 10.1007/BF02222209. Agents Actions. 1989. PMID: 2473645
-
An Optimized Protocol for the Isolation and Functional Analysis of Human Lung Mast Cells.Front Immunol. 2018 Oct 5;9:2193. doi: 10.3389/fimmu.2018.02193. eCollection 2018. Front Immunol. 2018. PMID: 30344519 Free PMC article.
-
Cromoglycate and nedocromil: influence on airway reactivity.Mediators Inflamm. 1994;3(7):S15-9. doi: 10.1155/S0962935194000694. Mediators Inflamm. 1994. PMID: 18475597 Free PMC article.
-
Antihistamines in the treatment of asthma.Clin Rev Allergy. 1994 Spring;12(1):65-78. doi: 10.1007/BF02815510. Clin Rev Allergy. 1994. PMID: 7915192 Review. No abstract available.
-
Effects of antihistamines on isolated human lung mast cells, basophil leucocytes and erythrocytes.Agents Actions. 1989 Apr;27(1-2):83-5. doi: 10.1007/BF02222205. Agents Actions. 1989. PMID: 2473642