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Editorial
. 2014 Feb;35(8):482-4.
doi: 10.1093/eurheartj/eht504. Epub 2013 Dec 25.

Moving catheter ablation forward from paroxysmal to persistent atrial fibrillation: progress, limitations, and surprises of the SARA trial

Gerhard Hindricks  1 , Douglas L Packer
Affiliations
Editorial

Moving catheter ablation forward from paroxysmal to persistent atrial fibrillation: progress, limitations, and surprises of the SARA trial

Gerhard Hindricks et al. Eur Heart J. 2014 Feb.
No abstract available

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Figures

Figure 1
Figure 1
Not all patients with persistent atrial fibrillation (AF) are the same: voltage maps from two patients with persistent AF taken during catheter ablation of AF. The purple area represents normal voltage, suggesting normal atrial myocardium, while the green, yellow, and red zones demark areas with reduced voltage and abnormal conduction properties. Grey demarks scarred tissue which is electrically unexcitable. Both patients present with the same AF ‘ECG phenotype’, i.e. persistent AF. However, patient A shows no intense atrial remodelling as compared with patient B showing extensive scars and low voltage areas along the roof and the posterior wall of the left atrium. The red tags demark circumferential ablation lines for isolation of the pulmonary veins.
See this image and copyright information in PMC

Comment on

References

    1. Calkins H, Kuck KH, Cappato R, Brugada J, Camm AJ, Chen SA, Crijns HJ, Damiano RJ, Jr, Davies DW, DiMarco J, Edgerton J, Ellenbogen K, Ezekowitz MD, Haines DE, Haissaguerre M, Hindricks G, Iesaka Y, Jackman W, Jalife J, Jais P, Kalman J, Keane D, Kim YH, Kirchhof P, Klein G, Kottkamp H, Kumagai K, Lindsay BD, Mansour M, Marchlinski FE, McCarthy PM, Mont JL, Morady F, Nademanee K, Nakagawa H, Natale A, Nattel S, Packer DL, Pappone C, Prystowsky E, Raviele A, Reddy V, Ruskin JN, Shemin RJ, Tsao HM, Wilber D. 2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: recommendations for patient selection, procedural techniques, patient managementand follow-up, definitions, endpoints, and research trial design. Europace. 2012;14:528–606. - PubMed
    1. Cosedis Nielsen J, Johannessen A, Raatikainen P, Hindricks G, Walfridsson H, Kongstad O, Pehrson S, Englund A, Hartikainen J, Mortensen LS, Hansen PS. A randomized comparison of radiofrequency ablation and antiarrhythmic drug therapy as first line treatment in paroxysmal atrial fibrillation. N Engl J Med. 2012;367:1587–1595. - PubMed
    1. Morillo C, Verma A, Kuck KH, Natale A. Radiofrequency ablation vs. antiarrhythmic drugs as first-line treatment of symptomatic atrial fibrillation: (RAAFT 2): a randomized trial. Heart Rhythm Society 2012 Scientific Sessions; May 11, 2012; Boston, MA. Abstract LB02-1. - PubMed
    1. Wilber DJ, Pappone C, Neuzil P, De Paola A, Marchlinski F, Natale A, Macle L, Daoud EG, Calkins H, Hall B, Reddy V, Augello G, Reynolds MR, Vinekar C, Liu CY, Berry SM, Berry DA ThermoCool AF. Trial Investigators. Comparison of antiarrhythmic drug therapy and radiofrequency catheter ablation in patients with paroxysmal atrial fibrillation: a randomized controlled trial. JAMA. 2010;303:333–340. - PubMed
    1. Packer DL, Kowal RC, Wheelan KR, Irwin JM, Champagne J, Guerra PG, Dubuc M, Reddy V, Nelson L, Holcomb RG, Lehmann JW, Ruskin JN STOP AF Cryoablation Investigators. Cryoballoon ablation of pulmonary veins for paroxysmal atrial fibrillation: first results of the North American Arctic Front (STOP AF) pivotal trial. J Am Coll Cardiol. 2013;61:1713–1723. - PubMed

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