Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Apr 30;2(3):92-3.
doi: 10.1016/j.gynor.2012.04.004. eCollection 2012.

Topical treatment of recurrent vaginal melanoma in situ with imiquimod: A case report

Affiliations

Topical treatment of recurrent vaginal melanoma in situ with imiquimod: A case report

Lauren S Prescott et al. Gynecol Oncol Case Rep. .

Abstract

► Vaginal melanoma in situ is a rare neoplasm with a paucity of data regarding the optimal management. ► More conservative approaches are needed to avoid the disfigurement, pain and postoperative complications associated with repeated surgical interventions. ► Imiquimod may prove to be a useful treatment modality for patients with vulvar or vaginal melanoma in situ.

Keywords: Imiquimod; Melanoma; Melanoma-in-situ; Vaginal neoplasm; Vulvar neoplasm.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Melanoma in situ: there is a diffuse proliferation of atypical epithelioid melanocytes along the basal layer (100 ×).

References

    1. Berek J.S., Hacker N.F. Practical Gynecologic Oncology. 2nd ed. Williams & Wilkins; Baltimore: 1994. pp. 576–586.
    1. Narayan R., Nguyen H., Bentow J.J., Moy L., Lee D.K., Greger S., Haskell J., Vanchinathan V., Chang P.L., Tsui S., Konishi T., Comin-Anduix B., Dauphine C., Vargas H.I., Economou J.S., Ribas A., Bruhn K.W., Craft N. Immunomodulation by imiquimod in patients with high-risk primary melanoma. J. Invest. Dermatol. 2012;132:163–169. - PMC - PubMed
    1. Tcheung W.J., Selim M.A., Herndon J.E., II, Abernethy A.P., Nelson K.C. Clinicopathologic study of 85 cases of melanoma of the female genitalia. J. Am. Acad. Dermatol. 2012 - PubMed
    1. Frumovitz M., Etchepareborda M., Sun C.C., Soliman P.T., Eifel P.J., Levenback C.F., Ramirez P.T. Primary malignant melanoma of the vagina. Obstet. Gynecol. 2010;116:1358–1365. - PubMed
    1. van Seters M., van Beurden M., ten Kate F.J., Beckmann I., Ewing P.C., Eijkemans M.J., Kagie M.J., Meijer C.J., Aaronson N.K., Kleinjan A., Heijmans-Antonissen C., Zijlstra F.J., Burger M.P., Helmerhorst T.J. Treatment of vulvar intraepithelial neoplasia with topical imiquimod. N. Engl. J. Med. 2008;358:1465–1473. - PubMed

LinkOut - more resources