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. 2012 Jul 3;1(1):45-8.
doi: 10.1016/j.mmcr.2012.06.003. eCollection 2012.

A case of onychomycosis caused by Aspergillus candidus

Bahram Ahmadi  1 , Seyed Jamal Hashemi  1 , Farideh Zaini  1 , Mohammad Reza Shidfar  1 , Maryam Moazeni  1 , Bita Mousavi  2 , Fatemeh Noorbakhsh  3 , Mohsen Gheramishoar  1 , Leila Hossein Pour  1 , Sassan Rezaie  4
Affiliations

A case of onychomycosis caused by Aspergillus candidus

Bahram Ahmadi et al. Med Mycol Case Rep. .

Abstract

Based on epidemiological studies, Aspergillus candidus has been demonstrated as an emerging fungal agent of toenail onychomycosis. Here we report a case of a toenail infection caused by A. candidus in a healthy 60-year-old woman. Based on macroscopic and microscopic characteristics of the culture as well as nucleotide sequencing of 28S region, the causative agent was identified as A. candidus.

Keywords: Aspergillus candidus; DNA sequencing; Onychomycosis.

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Figures

Fig. 1
Fig. 1
Clinical features of the toenail lesion caused by Aspergillus candidus. A total discolouration with a subungual hyperkeratosis is obviously observed.
Fig. 2
Fig. 2
15% KOH slide preparation of the nail scraping showed rather broad septate and irregular hyphae (×400).
Fig. 3
Fig. 3
Colony morphology of the causing agent of onychomycosis on Czapek Yeast Agar (CYA) after incubating at 25° C for 6 days. (a) The picture depicts a pale yellow colony. And the microscopic view of filaments after performing slide culture: (b) the fungus possesses white, typically globose, conidial heads producing globose or subglobose, smooth, thin-walled conidia with spherical vesicles and metulae cover the entire surface of the vesicle. (Scale bar: 2 μm.) (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.).
Fig. 4
Fig. 4
After 72 h of incubation at 35 °C, it was found that the isolate was resistant to Caspofungin with MIC>32 μg/mL and moderately susceptible to Fluconazole with MIC 2 μg/mL. However it was susceptible to Posaconazole with MICs 0.032 μg/mL.
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