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. 2014 Sep;16(9):830-5.
doi: 10.1111/hpb.12206. Epub 2013 Dec 24.

Actual 10-year survival following hepatectomy for hepatocellular carcinoma

Bernardo Franssen  1 , Ghalib Jibara, Parissa Tabrizian, Myron E Schwartz, Sasan Roayaie
Affiliations

Actual 10-year survival following hepatectomy for hepatocellular carcinoma

Bernardo Franssen et al. HPB (Oxford). 2014 Sep.

Abstract

Objectives: This study was conducted to compare 10-year survivors with patients who survived <10 years in a large Western series of patients submitted to hepatectomy for hepatocellular carcinoma (HCC).

Methods: A retrospective review of a series of hepatic resections conducted in a referral centre for HCC between January 1987 and October 2002 was conducted.

Results: A total of 176 patients were analysed. Twenty-eight patients survived ≥ 10 years (Group A) and were compared with the 148 patients who did not (Group B). Group A had smaller tumours (5.7 cm versus 8.2 cm; P = 0.001) and a lower incidence of microvascular invasion (18.5% versus 37.1%; P = 0.004). Recurrence did not differ significantly (Group A 18/28, 64.3% versus Group B 94/148, 63.5%). Median time to recurrence was longer in Group A (70 months versus 15 months; P < 0.0001), and more patients in Group A were able to undergo curative treatment for recurrence (88.8% versus 40.4%; P < 0.0001). Multivariate analysis showed that lack of vascular invasion (P = 0.020), absence of perioperative transfusion (P = 0.014), and recurrence at >2 years after primary resection (P = 0.045) were significantly associated with 10-year survival.

Conclusions: Ten-year survival after liver resection for HCC can be expected in approximately 15% of patients. Recurrence does not preclude longterm survival. Recurrence at >2 years after resection, absence of vascular invasion, and absence of perioperative transfusion are independently associated with 10-year survival.

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Figures

Figure 1
Figure 1
Kaplan–Meier curves showing (a) overall survival and (b) recurrence in the entire cohort of 176 patients submitted to hepatectomy for hepatocellular carcinoma
Figure 2
Figure 2
Kaplan–Meier curves for recurrence in patients who did and did not achieve 10-year survival after hepatectomy for hepatocellular carcinoma. LTS, longterm survivors
See this image and copyright information in PMC

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