Review
doi: 10.1016/B978-0-12-800101-1.00001-6.
G protein-coupled receptors as regulators of glucose homeostasis and therapeutic targets for diabetes mellitus
Affiliations
- PMID: 24373233
- DOI: 10.1016/B978-0-12-800101-1.00001-6
Item in Clipboard
Review
G protein-coupled receptors as regulators of glucose homeostasis and therapeutic targets for diabetes mellitus
Prog Mol Biol Transl Sci.
2014.
Abstract
As critical regulators of almost all physiological processes in the body, G protein-coupled receptors (GPCRs) are important regulators of glucose homeostasis. Some of the newer drugs for treating diabetes mellitus or in development are also targeting GPCRs. This chapter provides a summary of some of the GPCRs that have been shown to be involved in regulating glucose homeostasis.
Keywords: G protein-coupled receptor; Glucose homeostasis; Incretin; Neuropeptides; Pancreatic peptide.
© 2014 Elsevier Inc. All rights reserved.
Similar articles
-
G-protein-coupled receptors (GPCRs) in the treatment of diabetes: Current view and future perspectives.Best Pract Res Clin Endocrinol Metab. 2018 Apr;32(2):201-213. doi: 10.1016/j.beem.2018.02.005. Epub 2018 Mar 15. Best Pract Res Clin Endocrinol Metab. 2018. PMID: 29678286 Review.
-
Targeting GPR119 for the potential treatment of type 2 diabetes mellitus.Prog Mol Biol Transl Sci. 2014;121:95-131. doi: 10.1016/B978-0-12-800101-1.00004-1. Prog Mol Biol Transl Sci. 2014. PMID: 24373236 Review.
-
Current status of G-protein coupled receptors as potential targets against type 2 diabetes mellitus.Int J Biol Macromol. 2018 Oct 15;118(Pt B):2237-2244. doi: 10.1016/j.ijbiomac.2018.07.091. Epub 2018 Jul 17. Int J Biol Macromol. 2018. PMID: 30030074 Review.
-
MicroRNAs: 'ribo-regulators' of glucose homeostasis.Nat Med. 2006 Jan;12(1):36-8. doi: 10.1038/nm0106-36. Nat Med. 2006. PMID: 16397558 No abstract available.
-
Glucagon-like peptide-1, glucose homeostasis and diabetes.Trends Mol Med. 2008 Apr;14(4):161-8. doi: 10.1016/j.molmed.2008.01.003. Epub 2008 Mar 18. Trends Mol Med. 2008. PMID: 18353723 Review.
Cited by
-
Insights into Basal Signaling Regulation, Oligomerization, and Structural Organization of the Human G-Protein Coupled Receptor 83.PLoS One. 2016 Dec 9;11(12):e0168260. doi: 10.1371/journal.pone.0168260. eCollection 2016. PLoS One. 2016. PMID: 27936173 Free PMC article.
-
Chaperoning G protein-coupled receptors: from cell biology to therapeutics.Endocr Rev. 2014 Aug;35(4):602-47. doi: 10.1210/er.2013-1121. Epub 2014 Mar 24. Endocr Rev. 2014. PMID: 24661201 Free PMC article. Review.
-
The extracellular N-terminal domain of G-protein coupled receptor 83 regulates signaling properties and is an intramolecular inverse agonist.BMC Res Notes. 2014 Dec 16;7:913. doi: 10.1186/1756-0500-7-913. BMC Res Notes. 2014. PMID: 25516095 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
