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. 2013 Dec 28:12:189.
doi: 10.1186/1476-511X-12-189.

Lavender (Lavandula stoechas L.) essential oils attenuate hyperglycemia and protect against oxidative stress in alloxan-induced diabetic rats

Hichem Sebai, Slimen Selmi  1 , Kais Rtibi, Abdelaziz Souli, Najoua Gharbi, Mohsen Sakly
Affiliations

Lavender (Lavandula stoechas L.) essential oils attenuate hyperglycemia and protect against oxidative stress in alloxan-induced diabetic rats

Hichem Sebai et al. Lipids Health Dis. .

Abstract

Background: The present study described the phytochemical profile of Lavandula stoechas essential oils, collected in the area of Ain-Draham (North-West of Tunisia), as well as their protective effects against alloxan-induced diabetes and oxidative stress in rat.

Methods: Essential oils samples were obtained from the aerial parts of the plant by hydrodistillation and analyzed by GC-MS. Rats were divided into four groups: Healthy Control (HC); Diabetic Control (DC); Healthy + Essential Oils (H + EO) and Diabetic + Essential Oils (D + EO).Antidiabetic and antioxidant activities were evaluated after subacute intraperitoneally injection of Lavandula stoechas essential oils (50 mg/kg b.w., i.p.) to rats during 15 days.

Results: The principal compounds detected are: D-Fenchone (29.28%), α-pinene (23.18%), Camphor (15.97%), Camphene (7.83%), Eucapur (3.29%), Limonene, (2.71%) Linalool, (2.01%) Endobornyl Acetate (1.03%). The essential oils also contained smaller percentages of Tricyclene, Cymene, Delta-Cadinene, Selina-3,7(11)-diene. Furthermore, we found that Lavandula stoechas essential oils significantly protected against the increase of blood glucose as well as the decrease of antioxidant enzyme activities induced by aloxan treatment. Subacute essential oils treatment induced a decrease of lipoperoxidation as well as an increase of antioxidant enzyme activities.

Conclusions: These findings suggested that lavandula stoechas essential oils protected against diabetes and oxidative stress induced by alloxan treatment. These effects are in partly due to its potent antioxidant properties.

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Figures

Figure 1
Figure 1
Free radical-scavenging activity of Lavandula stoechas essential oils and ascorbic acid on 2,2-diphenyl-1-picrylhydrazyl (DPPH).
Figure 2
Figure 2
Subacute effect of Lavandula stoechas essential oils on acute aloxan-induced changes in liver and kidney MDA (A and B) and (−SH) groups (C and D) levels. Animals were treated during 15 days with Lavandula stoechas essential oils (50 mg/kg b.w., i.p.) or vehicle (NaCl 0.9%) sevan days after diabetic induction with alloxan at 220 mg/kg b.w.. Assays were carried out in triplicate. HC: Healthy Control; DC: Diabetic Control; H + EO: Healthy + Essential Oils; D + EO: Diabetic + Essential Oils. “a”: p < 0.05 compared to “Healthy Control” group and “b”: p < 0.05 compared to “Diabetic Control” group.
Figure 3
Figure 3
Subacute effect of Lavandula stoechas essential oils on acute aloxan-induced changes in liver and kidney CAT (A and B), Total SOD, Cu/Zn-SOD, Mn-SOD and Fe-SOD (C and D). Animals were treated during 15 days with Lavandula stoechas essential oils (50 mg/kg b.w., i.p.) or vehicle (NaCl 0.9%) sevan days after diabetic induction with alloxan at 220 mg/kg b.w.. Assays were carried out in triplicate. HC: Healthy Control; DC: Diabetic Control; H + EO: Healthy + Essential Oils; D + EO: Diabetic + Essential Oils. “a”: p < 0.05 compared to “Healthy Control” group and “b”: p < 0.05 compared to “Diabetic Control” group.
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