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Review
. 2014 Jan;43(1):66-73.
doi: 10.1016/j.lpm.2013.11.004. Epub 2013 Dec 27.

[Biomarkers in inflammatory bowel diseases]

[Article in French]
Xavier Roblin  1 , Alaric Cavaille  2 , Léa Clavel  3 , Stéphane Paul  4
Affiliations
Review

[Biomarkers in inflammatory bowel diseases]

[Article in French]
Xavier Roblin et al. Presse Med. 2014 Jan.

Abstract

Fecal calprotectine is of interest for diagnosis of IBD at the beginning. CRP and fecal calprotectine are predictive of long-term response in patients treated by anti-TNF therapy. Trough levels of anti-TNF are associated to clinical remission and mucosal healing. Detectable antibodies to anti-TNF are associated with lower response to treatment. Interventional studies are waiting before optimization of treatment in function of biomarkers. Trough levels of anti-TNF help to modify our treatment (optimization or de-escalation).

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