Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Mar;70(3):443-8.
doi: 10.1016/j.jaad.2013.11.008. Epub 2013 Dec 24.

Incidence of lentigo maligna in Olmsted County, Minnesota, 1970 to 2007

Sultan A Mirzoyev  1 , Richelle M Knudson  2 , Kurtis B Reed  2 , Jennifer L Hou  1 , Christine M Lohse  3 , Marcus L Frohm  2 , Jerry D Brewer  2 , Clark C Otley  2 , Randall K Roenigk  4
Affiliations

Incidence of lentigo maligna in Olmsted County, Minnesota, 1970 to 2007

Sultan A Mirzoyev et al. J Am Acad Dermatol. 2014 Mar.

Abstract

Background: The incidence of lentigo maligna (LM) may be increasing, but no population-based epidemiologic studies have been performed to our knowledge.

Objective: We sought to determine the incidence of LM in Olmsted County, Minnesota, along with overall and recurrence-free survival.

Methods: Using the Rochester Epidemiology Project, we identified all adult residents of Olmsted County, Minnesota, with a first lifetime diagnosis of LM between 1970 and 2007. Medical records were reviewed to determine demographic, clinical, and surgical data, and incidence and survival were calculated.

Results: Among 145 patients identified, median (range) age at diagnosis of LM was 70 (33-97) years. Treatment changed over time, with Mohs micrographic surgery becoming available after 1986. No patients died of LM; 5 had local recurrence. Estimated local recurrence-free survival at 5, 10, 15, and 20 years after diagnosis was 98%, 96%, 92%, and 92%, respectively. Overall age- and sex-adjusted incidence of LM among adults was 6.3 per 100,000 person-years, increasing from 2.2 between 1970 and 1989 to 13.7 between 2004 and 2007.

Limitations: Retrospective study design and homogeneous population are limitations.

Conclusion: The incidence of LM increased significantly among residents of Olmsted County, Minnesota, over an extended time frame, with incidence being significantly higher among men than women and increasing with age.

Keywords: Mohs micrographic surgery; Rochester Epidemiology Project; excision; incidence; lentigo maligna; lentigo maligna melanoma; melanoma; melanoma in situ.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: None.

Figures

Figure 1
Figure 1
Incidence of lentigo maligna by age at diagnosis and sex.
Figure 2
Figure 2
Incidence of lentigo maligna by calendar year of diagnosis and sex.
See this image and copyright information in PMC

References

    1. Newell GR, Sider JG, Bergfelt L, Kripke ML. Incidence of cutaneous melanoma in the United States by histology with special reference to the face. Cancer Res. 1988 Sep 1;48(17):5036–41. - PubMed
    1. Holman CD, Mulroney CD, Armstrong BK. Epidemiology of pre-invasive and invasive malignant melanoma in Western Australia. Int J Cancer. 1980 Mar 15;25(3):317–23. - PubMed
    1. Little JH, Holt J, Davis N. Changing epidemiology of malignant melanoma in Queensland. Med J Aust. 1980 Jan 26;1(2):66–9. - PubMed
    1. Smalberger GJ, Siegel DM, Khachemoune A. Lentigo maligna. Dermatol Ther. 2008 Nov-Dec;21(6):439–46. - PubMed
    1. Weinstock MA, Sober AJ. The risk of progression of lentigo maligna to lentigo maligna melanoma. Br J Dermatol. 1987 Mar;116(3):303–10. - PubMed

MeSH terms