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Review
. 2014 Mar-Apr:136-137:70-5.
doi: 10.1016/j.mad.2013.12.004. Epub 2013 Dec 25.

Maintenance of a healthy trajectory of the intestinal microbiome during aging: a dietary approach

Marco Candela  1 , Elena Biagi  2 , Patrizia Brigidi  2 , Paul W O'Toole  3 , Willem M De Vos  4
Affiliations
Review

Maintenance of a healthy trajectory of the intestinal microbiome during aging: a dietary approach

Marco Candela et al. Mech Ageing Dev. 2014 Mar-Apr.

Abstract

Sharing an intense transgenomic metabolism with the host, the intestinal microbiota is an essential factor for several aspects of the human physiology. However, several age-related factors, such as changes diet, lifestyle, inflammation and frailty, force the deterioration of this intestinal microbiota-host mutualistic interaction, compromising the possibility to reach longevity. In this scenario, the NU-AGE project involves the development of dietary interventions specifically tailored to the maintenance of a healthy trajectory of the intestinal microbiome, counteracting all processes connected to the pathophysiology of the human aging.

Keywords: Diet; Frailty; Healthy aging; Inflammation; Intestinal microbiota.

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