Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2014 Mar;78(3):313-5.
doi: 10.1016/j.diagmicrobio.2013.11.026. Epub 2013 Dec 6.

Rapid detection of Staphylococcus aureus and methicillin resistance in bone and joint infection samples: evaluation of the GeneXpert MRSA/SA SSTI assay

Florent Valour  1 , Viviane Blanc-Pattin  2 , Anne-Marie Freydière  3 , Anissa Bouaziz  4 , Emmanuel Chanard  5 , Sébastien Lustig  6 , Tristan Ferry  7 , Frédéric Laurent  8 ; Lyon Bone Joint Infection Study Group
Collaborators, Affiliations
Comparative Study

Rapid detection of Staphylococcus aureus and methicillin resistance in bone and joint infection samples: evaluation of the GeneXpert MRSA/SA SSTI assay

Florent Valour et al. Diagn Microbiol Infect Dis. 2014 Mar.

Abstract

The GeneXpert MRSA/SA SSTI assay was compared to conventional cultures to detect Staphylococcus aureus and methicillin-resistance from 91 bone and joint infection samples. Sensitivity and specificity were 94.4% and 100%. Three false-positive results were observed, in fact providing from patients known to be infected by S. aureus on the basis of other concomitant osteoarticular samples, which suggests that PCR was more sensitive than culture. This diagnosis accuracy may help shorten toxic and non-optimal empirical therapies such as glycopeptides in case of methicillin-susceptible strains.

Keywords: Bone and joint infection; GeneXpert MRSA/SA SSTI assay; Methicillin-resistance; Real time polymerase chain reaction; Staphylococcus aureus.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources