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Randomized Controlled Trial
. 2014 Jun;49(6):991-9.
doi: 10.1007/s00127-013-0808-6. Epub 2013 Dec 28.

Assessing outcomes of a stigma-reduction intervention with venue-based analysis

Affiliations
Randomized Controlled Trial

Assessing outcomes of a stigma-reduction intervention with venue-based analysis

Li Li et al. Soc Psychiatry Psychiatr Epidemiol. 2014 Jun.

Abstract

Purpose: A randomized controlled trial with a matched design was conducted during October 2008 and February 2010, aiming at reducing HIV-related stigma in healthcare settings.

Methods: Forty county hospitals in Fujian and Yunnan provinces of China were matched into pairs and randomized to either an intervention condition or a control condition. Forty-four service providers were randomly selected from each hospital, yielding a sample of 1,760. Intervention outcomes were assessed at baseline, 6 and 12 months based on venue-based pair comparisons. We identified and trained 30 popular opinion leaders in each intervention hospital among service providers to disseminate stigma-reduction messages to their peer providers.

Results: Hospital and participant characteristics were comparable between the intervention and control conditions. Thirteen out of twenty pairs of hospitals showed significant reduction in the stigma outcome measure at the 6-month follow-up assessment. For most hospitals, the intervention effects were maintained at the 12-month follow-up assessment. Among the 13 pair of hospitals, which showed intervention effects at 6 months, eight were in Fujian and five were in Yunnan. The non-significant hospitals at 6 months had more beds than significant hospitals. However, the difference did not reach statistical significance.

Conclusions: A matched design and venue-based analysis provide more insight in assessing intervention effects for facility-based intervention trials. The identification of venue-based or hospital characteristics that are associated with intervention efficacy provides additional implications for the adaptation and implementation of future interventions.

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Conflict of interest statement

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Figures

Figure 1
Figure 1
Flow of the participants and venues used in the study.
Figure 2
Figure 2
Estimated difference in stigma reduction (with 95% CI) at 6-month (left) and 12-month (right) follow-up assessments. The solid circle and the circle with plus symbol represent the estimated difference in stigma reduction for the intervention versus the control condition. The horizontal bar represents the 95% CI and the significance is indicated by one star (P < 0.05) or two stars (P < 0.0001).

References

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