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. 2014 Jan;28(1):59-62.
doi: 10.1002/jcla.21644. Epub 2013 Dec 27.

Antiadenohypophysis autoantibodies in patients with nongluten-related gastroenteropathies

Rocío Aguado  1 , Silvia Fernández, Orlando A Estévez, Manuel Santamaría, Consuelo Ortega
Affiliations

Antiadenohypophysis autoantibodies in patients with nongluten-related gastroenteropathies

Rocío Aguado et al. J Clin Lab Anal. 2014 Jan.

Abstract

Aim: To investigate the presence of antipituitary antibodies (APA) in the serum of patients undergoing gastroenteropathies (GEP) other than celiac disease (CD).

Methods: APA were analyzed in GEP patients (n = 103), CD patients (n = 94), idiopathic growth hormone (GH) deficiency patients (n = 21), and 98 age- and sex-matched controls. Indirect immunofluorescence was performed in cryostat sections of baboon pituitary gland.

Results: APA were detected in 30% of GEP patients, 38% of them showed failure to thrive. No significant differences were found when we compared thrive impairment in negative and positive APA GEP patients. Indeed, normal values of insulin-like growth factor 1 were found in 93% of positive APA GEP patients. APA were detected in 52% of the CD patients. Ninety-one percent of them, in contrast to GEP group, showed significant growth impairment (P < 0.05) when compared to APA negative CD individuals. GH-deficient non-CD patients did not show APA.

Conclusions: We have shown the presence of APA in patients with nongluten-related enteropathies. The presence of antipituitary autoantibodies in GEP patients does not seem to be associated with failure to thrive as it occurs in CD.

Keywords: antipituitary antibodies; celiac disease; gastroenterophaties; growth impairment; pituitary.

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Figures

Figure 1
Figure 1
Immunofluorescence in sera from GEP and healthy subjects were analyzed by indirect immunofluorescence. A speckled cytoplasmatic pattern is observed in GEP patients.
See this image and copyright information in PMC

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