Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Feb;60(2):156-60.
doi: 10.1111/j.1600-0773.1987.tb01516.x.

Muscarinic receptors activate calcium channels and calcium dependent potassium channels in NlE-115 neuroblastoma cells

B Hedlund, M Lorentz, P Arhem

Muscarinic receptors activate calcium channels and calcium dependent potassium channels in NlE-115 neuroblastoma cells

B Hedlund et al. Pharmacol Toxicol. 1987 Feb.

Abstract

Responses of NlE-115 neuroblastoma cells to application of carbachol were studied using intracellular recording techniques. Activation of muscarinic cholinergic receptors by carbachol resulted in a depolarization of the cells. The response was blocked by pirenzepine (1 microM) and by CoCl2 (5 mM), verapamil (10 microM) and gallopamil (10 microM), and prolonged by quinine (5 mM). It is suggested that muscarinic receptors increase the membrane calcium permeability, and that the influx of calcium activates calcium dependent potassium channels.

PubMed Disclaimer

Publication types

LinkOut - more resources