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. 2014 Mar 26;26(12):1886-93.
doi: 10.1002/adma.201304497. Epub 2013 Dec 23.

PEGylated WS(2) nanosheets as a multifunctional theranostic agent for in vivo dual-modal CT/photoacoustic imaging guided photothermal therapy

Liang Cheng  1 , Jingjing Liu, Xing Gu, Hua Gong, Xiaoze Shi, Teng Liu, Chao Wang, Xiaoyong Wang, Gang Liu, Huaiyong Xing, Wenbo Bu, Baoquan Sun, Zhuang Liu
Affiliations

PEGylated WS(2) nanosheets as a multifunctional theranostic agent for in vivo dual-modal CT/photoacoustic imaging guided photothermal therapy

Liang Cheng et al. Adv Mater. .

Abstract

A new generation of photothermal theranostic agents is developed based on PEGylated WS2 nanosheets. Bimodal in vivo CT/photoacoustic imaging reveals strong tumor contrast after either intratumoral or intravenous injection of WS2 -PEG. In vivo photothermal treatment is then conducted in a mouse tumor model, achieving excellent therapeutic efficacy with complete ablation of tumors. This work promises further exploration of transition-metal dichalcogenides for biomedical applications, such as cancer imaging and therapy.

Keywords: CT imaging; PAT imaging; Photothermal therapy; WS2 nanosheet.

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