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. 2014 Feb 15;30(4):588-9.
doi: 10.1093/bioinformatics/btt718. Epub 2013 Dec 28.

HTS navigator: freely accessible cheminformatics software for analyzing high-throughput screening data

Denis Fourches  1 , Maria F Sassano, Bryan L Roth, Alexander Tropsha
Affiliations

HTS navigator: freely accessible cheminformatics software for analyzing high-throughput screening data

Denis Fourches et al. Bioinformatics. .

Abstract

Summary: We report on the development of the high-throughput screening (HTS) Navigator software to analyze and visualize the results of HTS of chemical libraries. The HTS Navigator processes output files from different plate readers' formats, computes the overall HTS matrix, automatically detects hits and has different types of baseline navigation and correction features. The software incorporates advanced cheminformatics capabilities such as chemical structure storage and visualization, fast similarity search and chemical neighborhood analysis for retrieved hits. The software is freely available for academic laboratories.

Availability and implementation: http://fourches.web.unc.edu/

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Figures

Fig. 1.
Fig. 1.
Main window of the HTS Navigator program divided into three parts: (left) chemical information and properties of the current HTS project, (central) HTS data matrix (row = compound, column = target) colored by compounds potencies and (right) baseline controls as well as the HTS hit picker
See this image and copyright information in PMC

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References

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