Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013:2013:801974.
doi: 10.1155/2013/801974. Epub 2013 Nov 26.

Immunoexpression of interleukin-22 and interleukin-23 in oral and cutaneous lichen planus lesions: a preliminary study

Jun Chen  1 , Jinqiu Feng  2 , Xiangdong Chen  1 , Hui Xu  1 , Zengtong Zhou  3 , Xuemin Shen  3 , Zhexuan Bao  3 , Wei Liu  3 , Zhengyu Shen  1
Affiliations

Immunoexpression of interleukin-22 and interleukin-23 in oral and cutaneous lichen planus lesions: a preliminary study

Jun Chen et al. Mediators Inflamm. 2013.

Abstract

Interleukin- (IL-) 22 is the signature cytokine of T-helper (Th) 22 cells, and IL-23 is required for IL-22 production. The objective of this study was to examine the immunoexpression of IL-22 and IL-23 in archival paraffin-embedded biopsy specimens from oral LP (n = 42) and cutaneous LP (n = 38) against normal control tissues. The results showed that the percentage of cells expressing IL-22 and IL-23 in LP were significantly higher in LP compared to controls, respectively (both P < 0.001). The correlation between IL-22 and IL-23 expression was significant (P < 0.05). Moreover, the percentage of cells expressing IL-22 and IL-23 in oral LP were significantly higher than cutaneous LP (P < 0.05). Collectively, our findings demonstrated that the increased expression of IL-22 and IL-23 in LP lesions could play roles in the pathogenesis of LP. Moreover, oral LP expressing IL-22 and IL-23 was higher than cutaneous LP, probably due to Th22 cells as an important component of oral mucosal host defense against oral microbiota and tissue antigens. This may be associated with the difference in clinical behaviour of the two variants of the disease.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Representative expression pattern of IL-22: (a) negativity in normal oral mucosa and normal skin; (b) positivity in epithelial cells of oral and cutaneous lichen planus (LP); (c) positivity in subepithelial cells of oral and cutaneous LP. Magnification, ×200.
Figure 2
Figure 2
Representative expression pattern of IL-23: (a) negativity in normal oral mucosa and skin; (b) positivity in epithelial cells of oral and cutaneous lichen planus (LP); (c) positivity in subepithelial cells of oral and cutaneous LP. Magnification, ×200.
See this image and copyright information in PMC

References

    1. Baccaglini L, Thongprasom K, Carrozzo M, Bigby M. Urban legends series: lichen planus. Oral Diseases. 2013;19(2):128–143. - PubMed
    1. Farhi D, Dupin N. Pathophysiology, etiologic factors, and clinical management of oral lichen planus. Part I: facts and controversies. Clinics in Dermatology. 2010;28(1):100–108. - PubMed
    1. Roopashree MR, Gondhalekar RV, Shashikanth MC, George J, Thippeswamy SH, Shukla A. Pathogenesis of oral lichen planus: a review. Journal of Oral Pathology and Medicine. 2010;39(10):729–734. - PubMed
    1. Boyd AS, Neldner KH. Lichen planus. Journal of the American Academy of Dermatology. 1991;25(4):593–619. - PubMed
    1. Irvine C, Irvine F, Champion RH. Long-term follow-up of lichen planus. Acta Dermato-Venereologica. 1991;71(3):242–244. - PubMed

Publication types