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. 2010 Aug 4;15(4):79-86.
doi: 10.1016/j.rpor.2010.06.002. eCollection 2010.

Comparison between intensity modulated radiotherapy (IMRT) and 3D tangential beams technique used in patients with early-stage breast cancer who received breast-conserving therapy

Beata Sas-Korczyńska  1 , Anna Sladowska  2 , Bożena Rozwadowska-Bogusz  2 , Sonia Dyczek  3 , Jan Lesiak  2 , Anna Kokoszka  1 , Stanisław Korzeniowski  1
Affiliations

Comparison between intensity modulated radiotherapy (IMRT) and 3D tangential beams technique used in patients with early-stage breast cancer who received breast-conserving therapy

Beata Sas-Korczyńska et al. Rep Pract Oncol Radiother. .

Abstract

Background: The most often found complications in patients with breast cancer who received radiotherapy are cardiac and pulmonary function disorders and development of second malignancies.

Aim: To compare the intensity modulated radiotherapy with the 3D tangential beams technique in respect of dose distribution in target volume and critical organs they generate in patients with early-stage breast cancer who received breast-conserving therapy.

Materials and methods: A dosimetric analysis was performed to assess the three radiotherapy techniques used in each of 10 consecutive patients with early-stage breast cancer treated with breast-conserving therapy. Radiotherapy was planned with the use of all the three techniques: 3D tangential beams with electron boost, IMRT with electron boost, and intensity modulated radiotherapy with simultaneous integrated boost.

Results: The use of the IMRT techniques enables more homogenous dose distribution in target volume. The range of mean and median dose to the heart and lung was lower with the IMRT techniques in comparison to the 3D tangential beams technique. The range of mean dose to the heart amounted to 0.3-3.5 Gy for the IMRT techniques and 0.4-4.3 for the tangential beams technique. The median dose to the lung on the irradiated side amounted to 4.9-5 Gy for the IMRT techniques and 5.6 Gy for the 3D tangential beams technique.

Conclusion: The application of the IMRT techniques in radiotherapy patients with early-stage breast cancer allows to obtain more homogenous dose distribution in target volume, while permitting to reduce the dose to critical organs.

Keywords: Breast-conserving therapy; Early-stage breast cancer; Intensity modulated radiotherapy; Radiotherapy; Tangential beams technique.

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Figures

Fig. 1
Fig. 1
The arrangement of radiotherapy beams in three techniques used in postoperative treatment of patients with early-stage breast cancer treated with breast-conserving therapy.
Fig. 2
Fig. 2
The comparison of dose distribution in target volume in three techniques used in postoperative treatment of patients with early-stage breast cancer treated with breast-conserving therapy.
Fig. 3
Fig. 3
The comparison of dose-volume histograms (DVH) in target volume and critical organs in three techniques used in postoperative treatment of patients with early-stage breast cancer treated with breast-conserving therapy (3D tangential beams + electron boost, IMRT + electron boost, IMRT-SIB).
See this image and copyright information in PMC

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