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. 2012 Jun 5;17(4):237-42.
doi: 10.1016/j.rpor.2012.03.005. eCollection 2012.

Adyuvant fractionated radiotherapy after resection of intracranial hemangiopericytoma

Cristina Prado  1 , Arturo Navarro-Martin  2 , Ana Lucas  2 , Miquel Macià  2 , Ferran Guedea  2
Affiliations

Adyuvant fractionated radiotherapy after resection of intracranial hemangiopericytoma

Cristina Prado et al. Rep Pract Oncol Radiother. .

Abstract

Aim: Review of literature and adjuvant treatment in Hemangiopericytoma after complete resection.

Background: Intracranial hemangiopericytoma (HPC) is an uncommon malignant vascular tumor arising from mesenchymal cells with pericytic differentiation. Surgery remains the mainstay treatment, and adjuvant radiation therapy appears to be appropriate for patients with high grade tumors or incomplete resection. We present our experience and review of the literature.

Materials and methods: We describe two cases of intracranial hemangiopericytoma located in the frontal lobe of the CNS. Both patients underwent complete tumor resection followed by adjuvant fractionated radiotherapy and completed treatment without interruptions.

Results: A local recurrence was observed in one of these cases and fractionated stereotactic radiotherapy was performed. Both patients are alive and disease has been under control up to date.

Conclusion: The treatment of choice for intracranial hemangiopericytoma is a complete surgical resection as long as possible. Adjuvant radiotherapy of HPC can result in increased tumor control and should be considered as an effective treatment for patients with high grade or demonstrated residual tumor in the postoperative period. Salvage treatment using limited-field fractionated radiotherapy for local recurrence treatment is considered an acceptable option.

Keywords: Fractionated radiotherapy; Hemangiopericytoma; Radiotherapy; Stereotactic radiosurgery.

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Figures

Fig. 1
Fig. 1
A-B CT axial view. Bifrontal tumor at diagnosis.
Fig. 2
Fig. 2
A-B IMR axial and coronal view of local recurrence.
Fig. 3
Fig. 3
Treatment plan and dosimetric characteristics. (A) Dosimetric characteristics in relapse area and (B) treatment plan.
Fig. 4
Fig. 4
Tumor with marked cellularity and monotonous appearence of the tumor cells. The cells have oval nuclei with scant cytoplasm. A prominent vascular network is noted with thin walled vessels with a “staghorn” appearance. H&E 20×.
Fig. 5
Fig. 5
Treatment plan and dosimetrics characteristics.
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