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. 2012 Aug 9;17(6):363-6.
doi: 10.1016/j.rpor.2012.07.004. eCollection 2012.

Primary squamous cell carcinoma of the breast: A rare case report

Stefania Carbone  1 , Rosabel Lobo Alvarez  2 , Annalisa Lamacchia  3 , Asuncion Almenar Gil  4 , Raquel Martin Hernandez  5 , Jose Luis Lopez Guerra  1 , Hugo Marsiglia  6
Affiliations

Primary squamous cell carcinoma of the breast: A rare case report

Stefania Carbone et al. Rep Pract Oncol Radiother. .

Abstract

Background: Squamous cells are normally not found inside the breast. Therefore, a primary squamous cell carcinoma of the breast is an exceptional phenomenon and the management of this type of disease is still debated.

Aim: Clinical outcome assessment of a patient with squamous cell carcinoma of the breast.

Materials and methods: We report a case of primary squamous cell carcinoma of the breast (T1cN0M0) in a 51-years-old woman who underwent breast conserving surgery plus adjuvant chemotherapy and radiation therapy (RT).

Results: With a follow up of 43 months, the patient is alive with no evidence of local or distant recurrence. The patient had Grade 2 acute skin toxicity. No late skin or respiratory toxicity was observed.

Conclusions: Pure primary squamous cell carcinoma of the breast is a rare and aggressive disease, often treatment-refractory. Our case shows that the addition of RT after breast conserving surgery, allows to achieve a high local control without adding severe toxicity. A multidisciplinary approach seems to be the optimal management for early stages in this rare disease.

Keywords: Breast cancer; Outcome; Squamous cell carcinoma.

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Figures

Fig. 1
Fig. 1
Breast ultrasound showing an irregular shaped lesion containing liquid material.
Fig. 2
Fig. 2
Histology appearance of squamous cell carcinoma well-differentiated on hematoxylin and eosin stain showing (A) atypical keratinocytes and necrotic areas and (B) ductal dilatations, calcifications, and chronic flogosis.
See this image and copyright information in PMC

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