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. 2014 Feb 20;28(4):607-9.
doi: 10.1097/QAD.0000000000000170.

Generic antiretroviral drugs in developing countries: friends or foes?

David Zucman  1 , Seydou Camara, Jérome Gravisse, Svetlane Dimi, Marc Vasse, Abdon Goudjo, Marion Choquet, Gilles Peytavin
Affiliations

Generic antiretroviral drugs in developing countries: friends or foes?

David Zucman et al. AIDS. .

Abstract

Although second-line generic antiretroviral drugs are of great value in developing countries, there are concerns regarding their quality. We studied a generic Lopinavir/ritonavir (200/50 mg; Arga-L, India) marketed in the Republic of Congo but not prequalified by WHO. Despite adequate quantitative and qualitative drug content, Arga-L had a bio-availablility of 10% compared with Kaletra. To avoid selection of drug-resistant HIV, rigorous pharmacological monitoring of generic drugs not prequalified by WHO must be a priority.

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