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Review
. 2014 Jan;13(1):39-62.
doi: 10.1038/nrd4175.

Therapeutic targeting of EPH receptors and their ligands

Andrew W Boyd  1 , Perry F Bartlett  2 , Martin Lackmann  3
Affiliations
Review

Therapeutic targeting of EPH receptors and their ligands

Andrew W Boyd et al. Nat Rev Drug Discov. 2014 Jan.

Abstract

Critical roles for EPH receptor (EPH)-ephrin signalling in a range of chronic and regenerative diseases are increasingly being recognized. In particular, the complex roles of EPHs and ephrins in tumour growth and progression, and in nerve injury and regeneration have been studied extensively. This has led to considerable progress in developing strategies for their therapeutic targeting, with some anticancer agents already in clinical trials. Promising leads for non-malignant diseases are also emerging, with compelling preclinical data encouraging clinical development. We discuss this rapidly developing area of drug discovery, highlighting the associated challenges and limitations.

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References

    1. Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17305-10 - PubMed
    1. Oncogene. 2014 May 22;33(21):2737-47 - PubMed
    1. Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8778-83 - PubMed
    1. Nat Med. 2011 Sep 04;17(10):1225-7 - PubMed
    1. Cancer Res. 2006 Jul 15;66(14):7050-8 - PubMed

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