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. 2014 Jan;143(1):9-15.
doi: 10.1085/jgp.201311020.

Architectural and functional roles of A kinase-anchoring proteins in cAMP microdomains

Michael S Kapiloff  1 , Marc Rigatti, Kimberly L Dodge-Kafka
Affiliations

Architectural and functional roles of A kinase-anchoring proteins in cAMP microdomains

Michael S Kapiloff et al. J Gen Physiol. 2014 Jan.
No abstract available

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Figures

Figure 1.
Figure 1.
AKAP-orchestrated cAMP microdomains. (A) Formation of the cAMP microdomain occurs when the AKAP simultaneously associates with an AC, a PDE, PKA, and a substrate. Stimulation of AC increases cAMP (depicted in blue) surrounding the AKAP complex. (B) The increase in cAMP overcomes the basal activity of the PDE, allowing for PKA to become active and phosphorylate substrates in the complex, including the AC, PDE, and target protein. (C) Phosphorylation of the AC attenuates cAMP production, whereas PDE phosphorylation increases cAMP hydrolysis. These two acts decrease cAMP concentration, allowing for feedback inhibition of PKA.
See this image and copyright information in PMC

References

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