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Review
. 2014 May;69(5):1162-76.
doi: 10.1093/jac/dkt508. Epub 2013 Dec 29.

Therapeutic drug monitoring (TDM) of antifungal agents: guidelines from the British Society for Medical Mycology

H Ruth Ashbee  1 , Rosemary A Barnes, Elizabeth M Johnson, Malcolm D Richardson, Rebecca Gorton, William W Hope
Affiliations
Review

Therapeutic drug monitoring (TDM) of antifungal agents: guidelines from the British Society for Medical Mycology

H Ruth Ashbee et al. J Antimicrob Chemother. 2014 May.

Abstract

The burden of human disease related to medically important fungal pathogens is substantial. An improved understanding of antifungal pharmacology and antifungal pharmacokinetics-pharmacodynamics has resulted in therapeutic drug monitoring (TDM) becoming a valuable adjunct to the routine administration of some antifungal agents. TDM may increase the probability of a successful outcome, prevent drug-related toxicity and potentially prevent the emergence of antifungal drug resistance. Much of the evidence that supports TDM is circumstantial. This document reviews the available literature and provides a series of recommendations for TDM of antifungal agents.

Keywords: fungal diseases; fungal pathogens; triazoles.

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