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. 2013 Dec 14;19(46):8758-63.
doi: 10.3748/wjg.v19.i46.8758.

Association between TNF-α and IL-1β genotypes vs Helicobacter pylori infection in Indonesia

Yang Zhao  1 , Jing-Wen Wang  1 , Tsutomu Tanaka  1 , Akihiro Hosono  1 , Ryosuke Ando  1 , Shinkan Tokudome  1 , Soeripto  1 , F X Ediati Triningsih  1 , Tegu Triono  1 , Suwignyo Sumoharjo  1 , E Y Wenny Astuti Achwan  1 , Stephanus Gunawan  1 , Yu-Min Li  1
Affiliations

Association between TNF-α and IL-1β genotypes vs Helicobacter pylori infection in Indonesia

Yang Zhao et al. World J Gastroenterol. .

Abstract

Aim: To investigate the correlation between the Helicobacter pylori (H. pylori) infection and host genetic background of healthy populations in Indonesia.

Methods: In March 2007, epidemiological studies were undertaken on the general population of a city in Indonesia (Mataram, Lombok). The participants included 107 men and 187 women, whose ages ranged from 6 to 74 years old, with an average age of 34.0 (± 14.4) (± SD). The H. pylori of subject by UBT method determination, and through the polymerase chain reaction with confronting two-pair primers (PCR-CTPP) method parsing the single nucleotide polymorphism of interleukin (IL)-8, IL-4, IL-1β, CD14, tumor necrosis factor (TNF-α) and tyrosine-protein phosphates non-receptor type 11 (PTPN11) genotypes. The experimental data were analyzed by the statistical software SAS.

Results: The H. pylori infection rates in the healthy Indonesian population studied were 8.4% for men and 12.8% for women; no obvious differences were noted for H. pylori infection rates by sex or age. TC genotypes of IL-4, TC and CC genotypes of TNF-α, and GA genotypes of PTPN11, were higher in frequency. Both CC and TC genotype of TNF-α T-1031C loci featured higher expressions in the healthy Indonesian population Indonesia studied of (OR = 1.99; 95%CI: 0.67-5.89) and (OR = 1.66; 95%CI: 0.73-3.76), respectively. C allele of IL-1β T-31C gene locus was at a higher risk (OR = 1.11; 95%CI: 0.70-1.73) of H. pylori infection, but no statistical significance was found in our study.

Conclusion: We reveal that the association between the TNF-α and IL-1β genotypes may be the susceptibility of H. pylori in the studied population.

Keywords: Allele; Helicobacter pylori; Infection; Interleukin-1β; Tumor necrosis factor.

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References

    1. Backert S, Schwarz T, Miehlke S, Kirsch C, Sommer C, Kwok T, Gerhard M, Goebel UB, Lehn N, Koenig W, et al. Functional analysis of the cag pathogenicity island in Helicobacter pylori isolates from patients with gastritis, peptic ulcer, and gastric cancer. Infect Immun. 2004;72:1043–1056. - PMC - PubMed
    1. Vogiatzi P, Cassone M, Luzzi I, Lucchetti C, Otvos L, Giordano A. Helicobacter pylori as a class I carcinogen: physiopathology and management strategies. J Cell Biochem. 2007;102:264–273. - PubMed
    1. Brown LM. Helicobacter pylori: epidemiology and routes of transmission. Epidemiol Rev. 2000;22:283–297. - PubMed
    1. Brown LM, Thomas TL, Ma JL, Chang YS, You WC, Liu WD, Zhang L, Pee D, Gail MH. Helicobacter pylori infection in rural China: demographic, lifestyle and environmental factors. Int J Epidemiol. 2002;31:638–645. - PubMed
    1. Tokudome S, Soeripto FX, Ananta I, Suzuki S, Kuriki K, Akasaka S, Kosaka H, Ishikawa H, Azuma T, Moore MA. Rare Helicobacter pylori infection as a factor for the very low stomach cancer incidence in Yogyakarta, Indonesia. Cancer Lett. 2005;219:57–61. - PubMed

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