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Review
. 2013 Dec 19:7:19-22.
doi: 10.2147/CCID.S56673.

Once-daily topical treatment for psoriasis: calcipotriene + betamethasone two-compound topical formulation

Jonisha Shepherd  1 , Arash Taheri  1 , Steven R Feldman  2
Affiliations
Review

Once-daily topical treatment for psoriasis: calcipotriene + betamethasone two-compound topical formulation

Jonisha Shepherd et al. Clin Cosmet Investig Dermatol. .

Abstract

Background: Topical treatments are usually effective in mild psoriasis. However, the complexity of their use may result in low patient adherence with treatment. Combination of a vitamin D analog and a corticosteroid into a two-compound topical formulation has increased efficacy compared with either drug administered alone. Once-daily application of such a product would likely improve adherence. The purpose of this study was to determine whether twice-daily application of a calcipotriene + betamethasone topical formulation can provide improved clinical outcomes compared with once-daily treatment with the same product.

Methods: A review of the literature was performed seeking clinical trials comparing once-daily versus twice-daily application of calcipotriene + betamethasone topical formulations for the treatment of psoriasis.

Results: We found only one relevant clinical trial. This study showed similar efficacy and safety with once-daily versus twice-daily application of a topical calcipotriene + betamethasone formulation in the treatment of psoriasis vulgaris.

Conclusion: Once-daily application of a topical calcipotriene + betamethasone formulation may offer increased patient convenience and potentially increased patient adherence with long-term treatment, compared with twice-daily use, without reducing the efficacy. In order to enhance adherence, patient preference regarding frequency of application of topical treatments should be considered when prescribing medications.

Keywords: betamethasone; calcipotriene; combination product; once daily; psoriasis; twice daily.

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References

    1. Yentzer BA, Ade RA, Fountain JM, et al. Simplifying regimens promotes greater adherence and outcomes with topical acne medications: a randomized controlled trial. Cutis. 2010;86(2):103–108. - PubMed
    1. Richards HL, Fortune DG, O’Sullivan TM, Main CJ, Griffths CE. Patients with psoriasis and their compliance with medication. J Am Acad Dermatol. 1999;41(4):581–583. - PubMed
    1. Menter A, Gold LS, Bukhalo M, et al. Calcipotriene plus betamethasone dipropionate topical suspension for the treatment of mild to moderate psoriasis vulgaris on the body: a randomized, double-blind, vehicle-controlled trial. J Drugs Dermatol. 2013;12(1):92–98. - PubMed
    1. Fleming C, Ganslandt C, Guenther L, et al. Calcipotriol plus betamethasone dipropionate gel compared with its active components in the same vehicle and the vehicle alone in the treatment of psoriasis vulgaris: a randomised, parallel group, double-blind, exploratory study. Eur J Dermatol. 2010;20(4):465–471. - PubMed
    1. van de Kerkhof P, de Peuter R, Ryttov J, Jansen JP. Mixed treatment comparison of a two-compound formulation (TCF) product containing calcipotriol and betamethasone dipropionate with other topical treatments in psoriasis vulgaris. Curr Med Res Opin. 2011;27(1):225–238. - PubMed

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