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Review
. 2014 Aug;1842(8):1208-18.
doi: 10.1016/j.bbadis.2013.12.011. Epub 2013 Dec 29.

Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases

Li Gan  1 , Jeffrey A Johnson  2
Affiliations
Free article
Review

Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases

Li Gan et al. Biochim Biophys Acta. 2014 Aug.
Free article

Abstract

Oxidative damage contributes to pathogenesis in many neurodegenerative diseases. As the indicator and regulator of oxidative stress, the Nrf2-ARE pathway has been shown dynamic changes and examined for its neuroprotective role in many cases. In this review, we summarize the progress of the Nrf2-ARE pathway in combating toxicity induced from typical misfolded protein aggregates in neurodegenerative diseases, and specifically the effects on the clearance of protein aggregates.

Keywords: Misfolded proteins; Neurodegenerative diseases; Nrf2-ARE pathway; Oxidative stress.

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