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. 2013 Jul 8;7(2):1000059.
doi: 10.4172/1747-0862.1000059.

Small Molecule Targeting of PAI-1 Function: A New Therapeutic Approach for Treatment of Vascular Stenosis

Tessa M Simone  1 , Jaclyn Archambeault  1 , Paul J Higgins  1
Affiliations

Small Molecule Targeting of PAI-1 Function: A New Therapeutic Approach for Treatment of Vascular Stenosis

Tessa M Simone et al. J Mol Genet Med. .
No abstract available

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Figures

Figure 1
Figure 1. PAI-1 expression is upregulated within vascular smooth muscle cells of neointimal lesions
A-D.) Paraffin sections (5 µm) of ligated (A&C) and contralateral control (B&D) mouse, common, carotid arteries were subjected to PAI-1 (C&D) or smooth muscle cell α-actin (A&B) staining. Images taken with a 10x objective. E.) Rats were subjected to balloon-catheter endothelial denudation injury of the left common carotid artery. One week later, RNA was extracted from the injured carotids as well as the contralateral control arteries. Northern blot analysis of mRNA levels using 32P-labeled cDNA probes to PAI-1 and A50 (loading control).
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