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Review
. 2014 Jan;33(1):32-9.
doi: 10.5732/cjc.013.10207.

Standards of care and novel approaches in the management of glioblastoma multiforme

Andreas F Hottinger  1 , Roger Stupp, Krisztian Homicsko
Affiliations
Review

Standards of care and novel approaches in the management of glioblastoma multiforme

Andreas F Hottinger et al. Chin J Cancer. 2014 Jan.

Abstract

Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor in adults. Standard therapeutic approaches provide modest improvement in the progression-free and overall survival, necessitating the investigation of novel therapies. We review the standard treatment options for GBM and evaluate the results obtained in clinical trials for promising novel approaches, including the inhibition of angiogenesis, targeted approaches against molecular pathways, immunotherapies, and local treatment with low voltage electric fields.

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Figures

Figure 1.
Figure 1.. T1 post gadolinium sequence of magnetic resonance imaging (MRI) of a 46-year-old patient with a butterfly glioblastoma multiforme (GBM) invading the corpus callosum.
Figure 2.
Figure 2.. The standard treatment regimen for GBM that combines radiotherapy (RT) with temozolomide (TMZ).
*Prophylaxis against Pneumocystis Jirovecii was required for patients undergoing TMZ treatment during the concomitant phase.
See this image and copyright information in PMC

References

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