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Review
. 2014 Jan 1;4(1):a015529.
doi: 10.1101/cshperspect.a015529.

Induction of tolerance through mixed chimerism

David H Sachs  1 , Tatsuo Kawai, Megan Sykes
Affiliations
Review

Induction of tolerance through mixed chimerism

David H Sachs et al. Cold Spring Harb Perspect Med. .

Abstract

"Mixed chimerism" refers to a state in which the lymphohematopoietic system of the recipient of allogeneic hematopoietic stem cells comprises a mixture of host and donor cells. This state is usually attained through either bone marrow or mobilized peripheral blood stem cell transplantation. Although numerous treatment regimens have led to transplantation tolerance in mice, the induction of mixed chimerism is currently the only treatment modality that has been successfully extended to large animals and to the clinic. Here we describe and compare the use of mixed chimerism to establish transplantation tolerance in mice, pigs, monkeys, and in the clinic. We also attempt to correlate the mechanisms involved in achieving tolerance with the nature of the tolerance that has resulted in each case.

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Figures

Figure 1.
Figure 1.
Origin of haplotypes of inbred miniature swine.
See this image and copyright information in PMC

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